HA-1H T-Cell Receptor Gene Transfer to Redirect Virus-Specific T Cells for Treatment of Hematological Malignancies After Allogeneic Stem Cell Transplantation: A Phase 1 Clinical Study.

Graft-vs.-leukemia (GVL) reactivity after HLA-matched allogeneic stem cell transplantation (alloSCT) is mainly mediated by donor T cells recognizing minor histocompatibility antigens (MiHA). If MiHA are targeted that are exclusively expressed on hematopoietic cells of recipient origin, selective GVL reactivity without severe graft-vs.

Synthetic protein-sugar conjugates as models for the complement-inactivating property of atopic allergens.

Synthetic conjugates of β-lactoglobulin and reducing sugar prepared by Maillard reaction acquire the capacity of inactivating haemolytic complement in human serum. The C-inactivating potential is related to the mean number of (lysine)-ε-amino-1-deoxy-2-ketose residues incorporated in the model compound. These findings are compared to results obtained by skin-testing similar artificial allergens in atopic subjects.