Next-day effects of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on highway driving performance, memory functioning, psychomotor performance, and mood in healthy adult subjects.

Study Objectives: To evaluate the next-morning residual effects of ramelteon (8 mg), zopiclone (7.5 mg), and placebo on driving performance, memory functioning, psychomotor performance, and mood in healthy adult subjects following bedtime dosing and a middle of the night awakening.

Design: Single-center, randomized, double-blind, double-dummy, placebo-controlled, crossover study.

Effects of alcohol on highway driving in the STISIM driving simulator.

Objective: The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo.

Methods: Twenty-seven healthy young adults (14 men and 13 women; mean age (SD) = 22.