Publications by authors named "Liebmann J"
Purpose: To assess the effectiveness and cost of patient navigators in improving adherence to an initial in-office eye exam following community-based eye health screening and referral to ophthalmology among underserved populations.
Design: 5-year prospective, cluster-randomized clinical trial.
Participants: Eligible individuals aged 40 years and older were recruited from affordable housing developments and senior centers in Upper Manhattan.
Deep Learning Approach Predicts Longitudinal Retinal Nerve Fiber Layer Thickness Changes.
Bioengineering (Basel)
January 2025
This study aims to develop deep learning (DL) models to predict the retinal nerve fiber layer (RNFL) thickness changes in glaucoma, facilitating the early diagnosis and monitoring of disease progression. Using the longitudinal data from two glaucoma studies (Diagnostic Innovations in Glaucoma Study (DIGS) and African Descent and Glaucoma Evaluation Study (ADAGES)), we constructed models using optical coherence tomography (OCT) scans from 251 participants (437 eyes). The models were trained to predict the RNFL thickness at a future visit based on previous scans.
View Article and Find Full Text PDFPurpose: To investigate the association between optic disc size and circumpapillary retinal nerve fiber layer (cpRNFL) thinning in eyes with preperimetric glaucoma and glaucoma.
Design: Observational cohort.
Participants: A total of 841 eyes (554 primary open angle glaucoma [POAG] and 287 preperimetric glaucoma) from 553 patients who had at least 4 visits and 2 years of follow-up using optical coherence tomography.
Purpose: To assess the relationships between rates of glaucomatous visual field (VF) progression, fear of falling, history of falls, and ancestry.
Design: Prospective, multi-center, longitudinal cohort.
Subjects: Patients followed in the multi-site African Descent and Glaucoma Evaluation Study (ADAGES) with primary open-angle glaucoma and who completed a validated fear of falling questionnaire along with self-reported history of falls in the past year were enrolled.
Purpose: To examine the nine-item National Eye Institute Vision Function Questionnaire (NEI-VFQ-9) scores at baseline and 12 months in participants enrolled in the Manhattan Vision Screening and Follow-up Study (NYC-SIGHT) and determine factors associated with improvements in vision-related quality-of-life (VRQOL).
Methods: Retrospective review of NEI-VFQ-9 scores at baseline and 12-month follow-up in a community-based eye health screening study conducted in Upper Manhattan, New York. Participants were age ≥ 40 years and older, living independently in public/affordable housing developments and able to provide informed consent.
Prcis: Community-based eye health screenings that incorporated fundus photography and optometric exams in a high-risk NYC population effectively identified a higher than average number of participants that required an in-office glaucoma evaluation.
Purpose: To report glaucoma screening rates and risk factors associated with referral for in-office glaucoma evaluation in the Manhattan Vision Screening and Follow-up Study (NYC-SIGHT).
Methods: In this 5-year, cluster-randomized clinical trial, eligible individuals aged 40 and older were recruited from affordable housing developments and senior centers.
Purpose: To describe an accessible method of structure-function correlation using optical coherence tomography (OCT) and virtual reality perimetry (VRP) for patients with retinal disease and glaucoma and to compare results with those of conventional Humphrey visual fields (HVF).
Methods: Patients with a diagnosis of glaucoma involving the central visual field or macula-involving retinal disease were recruited. Patients underwent ophthalmic examination followed by OCT imaging, HVF, and VRP testing.
Background: To evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT).
Materials And Methods: From multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years.
Purpose: To evaluate RETFound, a foundation artificial intelligence model, using a diverse clinical research dataset to assess its accuracy in detecting glaucoma using optic disc photographs. The model's accuracy for glaucoma detection was evaluated across race, age, glaucoma severity, and various training cycles (epochs) and dataset sample sizes.
Design: Evaluation of a diagnostic technology.
Purpose: To determine the rate of visual field (VF) loss before and after the diagnosis of primary open angle glaucoma (POAG) in the Ocular Hypertension Treatment Study (OHTS).
Design: Prespecified analyses of data collected prospectively in a clinical trial with extended follow-up.
Setting And Participants: Participants who developed POAG during OHTS 1 and 2 (February 1994 to December 2008) constitute an inception cohort.
Article Synopsis
- Long-term changes in blood pressure may impact the progression of visual field (VF) loss in glaucoma patients, suggesting a potential link between cardiovascular health and vision deterioration.
- The study analyzed data from 985 glaucoma patients over an average follow-up period of 8 years, focusing on blood pressure measurements and VF testing from 2000 to 2022.
- Results indicated that higher average blood pressure and increased blood pressure variability were associated with more rapid VF loss, highlighting the importance of monitoring blood pressure in glaucoma management.
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View Article and Find Full Text PDFArticle Synopsis
- The study proposes a deep learning method to predict areas on optical coherence tomography (OCT) reports that ophthalmologists are likely to focus on, using eye tracking data.
- By analyzing eye movement patterns of ophthalmology professionals, they trained a U-Net model to identify these focus areas effectively.
- The results showed that their model achieved a precision of 0.723, indicating its potential to enhance glaucoma diagnosis and contribute to medical education by highlighting important regions in OCT reports.
Purpose: To examine the time to glaucoma progression detection by retinal nerve fiber layer thickness (RNFLT) and visual field (VF) among individuals of African descent (AD).
Design: Retrospective cohort study.
Methods: This multicenter study included eyes with glaucoma from individuals of AD from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study with ≥2 years/5 visits of optic nerve head RNFLT and 24-2 VF examinations.
Purpose Of Review: To explore a view of the human microbiome as an interconnected, functional, dynamic system that may be linked to the pathogenesis and progression of glaucoma.
Methods: A literature review was undertaken that included publications from 1966 to 2023.
Results: Bacterial lipopolysaccharides (LPS) activate toll-like receptors (TLR) and mediate the human immune response.
Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT) in primary open-angle glaucoma (POAG) in eyes of African (AD) and European descent (ED).
Design: Comparative diagnostic accuracy analysis by race.
Participants: 379 healthy eyes (125 AD and 254 ED) and 442 glaucomatous eyes (226 AD and 216 ED) from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study.
Background: To investigate the feasibility of using the Stopping Elderly Accidents, Deaths and Injuries (STEADI) Falls Risk Tool Kit during community-based eye health screenings to assess falls risk of participants enrolled in the Manhattan Vision Screening and Follow-Up Study (NYC-SIGHT).
Methods: Cross-sectional analysis of data from a 5-year prospective, cluster-randomised clinical trial conducted in affordable housing developments in New York City in adults age 40 years and older. Prescreening questions determined whether participants were at risk of falling.
Prcis: Using optical coherence tomography (OCT), eyes with advanced glaucoma were found to have a wide range of patterns of damage that were consistent with the natural history of progression based on a model of macular progression.
Purpose: To understand the patterns of preserved retinal ganglion cells in eyes with advanced glaucoma using OCT and a model of progression of the central macula.
Methods: OCT GCL thickness was measured in 94 eyes with advanced glaucoma, defined as glaucomatous eyes with a 24-2 MD (mean deviation) worse than -12 dB.
Purpose: To evaluate the association of mean intraocular pressure (IOP) and IOP variability (IOP fluctuation [SD of IOP] and the IOP range) with the rate of ganglion cell complex (GCC) layer thinning over time in patients with glaucoma.
Design: Prospective cohort study.
Methods: Participants with at least 4 visits and 2 years of follow-up of optical coherence tomography tests were included.
There are several ongoing, worldwide clinical trials with a cumulative target enrollment of over 1300 participants on the role of nicotinamide (a specific form of vitamin B3) as a therapeutic neuroprotective treatment for glaucoma. We describe a serious adverse event of drug-induced liver injury (DILI) likely related to the use of 3 g/day nicotinamide in a glaucoma clinical trial (clinicaltrials.gov identifier: NCT05695027) based in the United States.
View Article and Find Full Text PDFClinical Relevance: Optometrists can play a key role in providing access to eye care in underserved populations by organising community-based eye health screenings that include optometric exams to detect vision impairment and uncorrected refractive error.
Background: Community-based eye health screenings and optometric exams were conducted in the NYC-SIGHT Study.
Methods: A sub-analysis of vision impairment and refractive error results within a 5-year prospective, cluster-randomised clinical trial.