[Long-term antihypertensive therapy with urapidil. A 3-year open, multicenter trial of tolerance, safety and effectiveness].

Within the framework of an open, multicenter study of 16 physicians treated 206 hypertensive patients with a daily dose of 2 x 30 mg to 2 x 90 mg of urapidil over a period of 3 years. Data are available on 182 patients for the entire study period. 24 patients discontinued the study due to adverse effects (n = 2), an inadequate effect (n = 2), or for reasons unrelated to therapy (n = 20); 58 (28.

[Effect of thiopental anesthesia on plasma renin, adrenaline and noradrenaline in neurosurgical operations with induced hypotension].

Excessive postoperative blood pressure reactions following surgery of cerebral aneurysms using sodium nitroprusside--induced hypotension can be avoided, if barbiturate-fentanyl-anaesthesia is employed instead of neuroleptanalgesia. Plasma renin activity (PRA), plasma concentration of adrenaline and noradrenaline were determined in 13 patients, undergoing surgery of cerebral aneurysms with induced hypotension (group I) and in 15 patients, who were operated on for brain tumors without hypotension (group II). The PRA was not increased in group II.

Role of sodium and water in hypertensive patients on maintenance hemodialysis.

In 46 patients of the chronic hemodialysis program blood pressure regulation was studied according to variations of sodium and fluid balance. A strong relationship was observed between blood pressure and the amount of exchangeable sodium. In the hypertensive patients exchangeable sodium was increased depite fulfilled clinical signs of sufficient dehydration.