Overexpression of MMSET is correlation with poor prognosis in hepatocellular carcinoma.

The multiple myeloma SET domain (MMSET) involved in the t(4;14)(p16;q32) chromosomal translocation encodes a histone lysine methyltransferase. High expression of MMSET is common translocation in multiple myeloma (MM) and is associated with the worst prognosis. Recent studies have shown that overexpression of MMSET is significant in other tumor types compared to their normal tissues.

Growth arrest-specific homeobox is associated with poor survival in patients with hepatocellular carcinoma.

Growth arrest-specific homeobox (GAX) codes for a transcription factor and plays a crucial role in many human cancers. Previous tumor studies have shown GAX may act as a suppressor of growth, invasion, and metastasis. However, little is known as to its role in hepatocellular carcinoma (HCC).