Publications by authors named "Lidiya P Petrova"
Concanavalin A is a legume lectin which preferentially agglutinates transformed cells and shows antitumor effects on human breast carcinoma cells in vitro and in vivo. It is considered as a new potential antineoplastic agent targeting apoptosis, autophagy, and anti-angiogenesis in preclinical or clinical trials for cancer therapeutics, which has recently become the object of intensive study. In the present investigation, we show the capacity of the lectin to bind manganese, gold, iron, and zinc porphyrins: all potential anticancer agents.
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- Many cancer drugs, like cisplatin, hurt healthy cells too and can cause bad side effects, but they are still used to treat cancers like sarcomas and carcinomas.
- Wheat germ agglutinin (WGA) is a special protein that can find and stick to cancer cells, making it a good target for new cancer treatments.
- Research showed that certain metal-based drugs, like Pt porphyrin, stick to WGA much better than cisplatin, suggesting WGA might help deliver cancer drugs more effectively to tumors.