Publications by authors named "Lidiane M A de Lima"
Vanadium compounds are known to exert insulin-enhancing activity, normalize elevated blood glucose levels in diabetic subjects, and show significant activity in models of insulin resistance (IR). Faced with insulin resistance, the present work investigates the antidiabetic performance of a known oxidovanadium(IV)-based coordination compound-[VO(octd)]-and effects associated with glucocorticoid-induced insulin resistance in mice. The effects of [VO(octd)] were evaluated in a female Swiss mice model of insulin resistance induced by seven days of dexamethasone treatment in comparison with groups receiving metformin treatment.
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- - Polyoxovanadates (POV) are a type of polyoxometalate (POM) with potential biological effects; this study evaluates the toxicity of pentadecavanadate (V) on human blood cells and mice.
- - Cytotoxicity tests showed that V has a high cytotoxic effect on peripheral blood mononuclear cells at concentrations of about 17.5 μmol L, and while acute exposure in mice showed no immediate toxicity, repeated doses over 28 days revealed harmful effects.
- - The toxicity was linked to oxidative stress and changes in metabolic health indicators of the kidney and liver, suggesting that POVs like V could pose risks in biomedical use, especially given the study's findings of treatment-related mortality
(Fabaceae), known popularly as pata-de-vaca and mororó has been largely recommended treating several diseases in folk medicine. However, information on safe doses and use is still scarce. The goal was to evaluate antioxidant and antihemolytic and also acute and sub-acute toxicity effects of hydroalcoholic extract from leaves (HaEBcl).
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