Osteonecrosis is the death of bone cells due to insufficient blood supply; radiotherapy for various underlying malignancies is one of the uncommon causes. Microvascular damage or underlying tissue fibrosis, which leads to an ischemic environment and cell death, is a proposed mechanism. Factors influencing risk of radiation induced AVN include type of radiation whether external beam radiotherapy or brachytherapy, age of the patient, included body part and concomitant additional steroid or chemotherapy treatment.
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