Apelin-13 improves pulmonary epithelial barrier function in a mouse model of LPS-induced acute lung injury by inhibiting Chk1-mediated DNA damage.

Apelin-13, a type of active peptide, can alleviate lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, the specific mechanism is unclear. Cell cycle checkpoint kinase 1 (Chk1) plays an important role in DNA damage.

Apoptotic Bodies Derived from Fibroblast-Like Cells in Subcutaneous Connective Tissue Inhibit Ferroptosis in Ischaemic Flaps via the miR-339-5p/KEAP1/Nrf2 Axis.

Preventing and treating avascular necrosis at the distal end of the flaps are critical to surgery success, but current treatments are not ideal. A recent study shows that apoptotic bodies (ABs) generated near the site of apoptosis can be taken up and promote cell proliferation. The study reveals that ABs derived from fibroblast-like cells in the subcutaneous connective tissue (FSCT cells) of skin flaps promoted ischaemic flap survival.

FGF10 protects against LPS-induced epithelial barrier injury and inflammation by inhibiting SIRT1-ferroptosis pathway in acute lung injury in mice.

Pulmonary alveolar epithelial cell injury is considered the main pathological and physiological change in acute lung injury. Ferroptosis in alveolar epithelial cells is one of crucial factors contributing to acute lung injury (ALI). Therefore, reducing ferroptosis and repair epithelial barrier is very necessary.

FGF10 ameliorates lipopolysaccharide-induced acute lung injury in mice the BMP4-autophagy pathway.

Damage to alveolar epithelial cells caused by uncontrolled inflammation is considered to be the main pathophysiological change in acute lung injury. FGF10 plays an important role as a fibroblast growth factor in lung development and lung diseases, but its protective effect against acute lung injury is unclear. Therefore, this study aimed to investigate protective effect and mechanism of FGF10 on acute lung injury in mice.

Antioxidant mitoquinone ameliorates EtOH-LPS induced lung injury by inhibiting mitophagy and NLRP3 inflammasome activation.

Chronic ethanol abuse is a systemic disorder and a risk factor for acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). However, the mechanisms involved are unknown. One explanation is that ethanol produces damaging reactive oxygen species (ROS) and disturbs the balance of mitochondria within the lungs to promote a pro-injury environment.

Sensitive detection of radio-frequency field phase with interacting dark states in Rydberg atoms.

An efficient scheme of phase measurement of a radio-frequency (RF) field is proposed by interacting dark states. Under the condition of electromagnetically induced transparency (EIT), the four-level Rydberg atom exhibits two windows. Compared with the transmission spectrum on resonance, the linewidths of absorption peaks off resonance are very narrow due to the interaction of double dark states.

Apelin-13-Mediated AMPK ameliorates endothelial barrier dysfunction in acute lung injury mice via improvement of mitochondrial function and autophagy.

Maintaining the pulmonary endothelial barrier that prevents the exudation of inflammatory factors and proteins is the key to the treatment of acute lung injury (ALI). Apelin-13 plays an important role in vascular diseases; however, the protective effects of Apelin-13 on ALI with pulmonary endothelial barrier are unknown. Therefore, mice and human umbilical vein endothelial cells (HUVECs) were injured by LPS following Apelin-13 administration.

Severity of early allograft dysfunction following donation after circulatory death liver transplantation: a multicentre study.

Background: Early allograft dysfunction (EAD) is associated with decreased graft and patient survival rates. This study aimed to identify the severity of EAD and develop a predictive model for EAD after donation after circulatory death (DCD) liver transplantation (LT). Furthermore, the influence of operative time on EAD incidence was also evaluated.

Proposal of Rydberg atomic receiver for amplitude-modulated microwave signals with active Raman gain.

An efficient scheme for a microwave (MW) receiver is proposed based on the active Raman gain (ARG) in Rydberg atoms. The atoms are excited to the Rydberg state (53), and the gain spectrum has a single gain peak. The MW field is resonant with the Rydberg transition (53→54), resulting in a split in the gain spectrum.

A Rare 3D Porous Inorganic-Organic Hybrid Polyoxometalate Framework Based on a Cubic Polyoxoniobate-Cupric-Complex Cage with a High Water Vapor Adsorption Capacity.

A rare 3D porous inorganic-organic polyoxoniobate framework based on the cubic polyoxoniobate-cupric-complex cage {[Cu(en)]@{[Cu(en)(trz)](NbO)}} (), has been successfully synthesized by a hydrothermal method. The cubic cages are connected with 4-(tetrazol-5-yl)pyridine to form a 1D pillar-like chain structure, and every 1D pillar-like chain is further linked with four adjacent pillar-like chains by the [Cu(en)] complex to form a 3D porous inorganic-organic polyoxoniobate framework with 4-connected CdSO-type topology. To our knowledge, it is the first time that three different types of organic ligands are simultaneously introduced into one polyoxoniobate.

All-inorganic open frameworks based on gigantic four-shell Ln@W@Ln@(SiW) clusters.

A series of POM-based all-inorganic open frameworks, H[LnW(μ-O)(μ-O)(HO)](SiWO)·60HO (1-Ln, Ln = La, Pr and Nd), have been fabricated and structurally characterized for the first time. The unique architectures are constructed from nanoscale four-shell Ln@W@Ln@(SiW) clusters. Additionally, the porous nature of the frameworks has also been investigated.

A new type of composite MOFs based on high-valent Sb(v)-based units and cuprous-halide clusters.

An unusual high-valent Sb(v)-based unit [SbL] (L = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol) was developed for the first time to combine with various cuprous-halide clusters for the construction of a brand-new class of heterometallic MOFs. This work not only promotes the limited development of Sb-based MOFs, but also provides a practical strategy for developing new types of composite materials.

Preoperative risk stratification for early recurrence of HBV-related hepatocellular carcinoma after deceased donor liver transplantation: a five-eight model development and validation.

Background: Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of post-LT HCC recurrence.

Methods: Data of 748 adult patients who underwent deceased donor LT for HCC between January 2015, and February 2019 were collected retrospectively from the China Liver Transplant Registry database and randomly divided into training (n = 486) and validation(n = 262) cohorts.

Inorganic-organic hybrid high-dimensional polyoxotantalates and their structural transformations triggered by water.

The first two inorganic-organic hybrid three-dimensional (3D) polyoxotantalates (POTas) and the first two inorganic-organic hybrid 2D POTas have been obtained. All of these high-dimensional POTas are built from a new-type POTa dimeric cluster {Cu(en)(Ta6O19)}2/{Cu(enMe)(Ta6O19)}2 (en = ethylenediamine, enMe = 1,2-diaminopropane) bridged by copper complexes. Interestingly, extended POTas 1 and 3 can undergo single-crystal to single-crystal structural transformations triggered by water.

Development of a new Lindqvist-like Fe6 cluster secondary building unit for MOFs.

This work demonstrates a new Lindqvist-like [FeIII6(μ6-O)L4Cl6]2- (Fe6, L = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol) cluster for the construction of a novel class of Fe-cluster organic frameworks. The novel Fe6 cluster can be used to build not only a homometallic MOF, but also a heterometallic MOF by introducing copper halide clusters to the reaction system. In particular, the heterometallic MOF achieved a skillful combination of Fe6 SBU and cuprous-halide clusters for the first time.

Prediction of Early Recurrence of Hepatocellular Carcinoma in Patients with Cirrhosis Who Had Received Deceased Donor Liver Transplantation: A Multicenter Study.

BACKGROUND Early recurrence after liver transplantation (LT) is still a clinical problem. This multicenter study evaluated the Milan, Hangzhou, and AFP model-based criteria for prediction of early recurrence of HCC in patients with cirrhosis who had undergone LT. MATERIAL AND METHODS From the China Liver Transplant Registry (CLTR) database, we analyzed data of 589 HCC patients who had undergone LT between Jan 2015 and Jan 2019.

A nested Cu@Cu-based copper-organic polyhedral framework for selective adsorption of cationic dyes.

A nested Cu24@Cu72 copper-organic framework, [Cu5(bdc)4(ina)2(H2O)3]·solvent (1, H2bdc = 1,3-benzenedicarboxylic acid and Hina = isonicotinic acid) based on paddlewheel Cu2(COO)4 SBUs, has been synthesized. There are three types of cages with different sizes and shapes: Cu24-cage, Cu60-cage and Cu72-cage. The Cu72-cage, which is the highest-nuclearity Cu-cage reported to date, encapsulates a Cu24-cage to form a double-walled Cu24@Cu72 cage-within-cage structure.

Construction of Two High-Nuclear 3d-4d Heterometallic Cluster Organic Frameworks by Introducing a Bifunctional Tripodal Alcohol as a Structure-Directing Agent.

Two unique heterometallic cluster organic frameworks, [Cd Mn Mn (Tri) (CH COO) (μ -O) (μ -O) (H O) ] Cd(H O) ⋅9 H O (1) and Cu[Cd Cu (Tri) (CH COO) (H O) ] (CH COO) ⋅24 H O (2) (H Tri=2-(hydroxymethyl)-2-(pyridine-4-yl)-1,3-propanediol), have been successfully prepared by employing a bifunctional tripodal alcohol ligand as a structure-directing agent. Crystal structure analyses reveal that 1 represents a rare example of frameworks constructed from Cd-Mn heterometallic chains, and 2 is the first heterometallic MOF based on highest-nuclear Cd-Cu heterometallic cluster building blocks. Furthermore, the magnetic properties and gas adsorption abilities of 1 and 2 were systematically studied.

A Chromium-Substituted Polyoxoniobate with High Ionic Conductivity.

A rare and novel Cr-substituted polyoxoniobate (PONb), [CrNbO(OH)(HO)], has been synthesized by a combination of hydrothermal and conventional solution methods. The PONb shows an unknown tetrameric structure, which is the largest Cr-containing PONb to date. Interestingly, every two PONb tetramers can be joined together by alkali-metal cations to form a discrete cubelike ionic cluster.

All-Inorganic Ionic Porous Material Based on Giant Spherical Polyoxometalates Containing Core-Shell K @K -Water Cage.

This work demonstrates that the use of high-negative and high-symmetry lacunary polyoxometalates (POMs) for the clustering of alkali metal ions is a feasible strategy not only for the formation of rare high-nuclearity alkali-metal clusters but also for the construction of new-type all-inorganic ionic porous materials. By the strategy, an unprecedented high-nuclearity K-H O cluster {K (H O) } with core-shell K @K configuration is stabilized by 8 C -symmetry trivacant POMs [GeW O ] , forming a novel giant ionic alkali-metal-POM composite cluster {K Ge W O (H O) } with more than 100 metal centers. The incorporated 42-nuclearity K-H O cluster {K (H O) } exhibits the highest-nuclearity alkali-metal-water cluster known to date in POM chemistry.

Recent Advances in Zeolite-like Cluster Organic Frameworks.

During the past decade, research on the design and synthesis of zeolite-like metal-organic frameworks (ZMOFs) has developed greatly. As an important subclass of ZMOFs, zeolite-like cluster organic frameworks (ZCOFs) built from 4-connected metal-cluster secondary building units (SBUs) and appropriate linear organic ligand bridges have attracted sustained interest, because such materials not only integrate the merits of inorganic zeolites, ZMOFs, and metal clusters, including interesting topologies, high surface areas, extra-large cavities and channels, structural tunability, and unique physicochemical properties from various metal clusters, but also open up a new avenue to design and fabricate hybrid zeolite-like materials that have many potential applications in material sciences. In this review, recent developments in ZCOFs are summarized by classifying the ZCOFs into four categories according to the composition of the SBUs: 1) ZCOFs based on metal-halide cluster SBUs, 2) ZCOFs based on metal-oxygen cluster SBUs, 3) ZCOFs based on metal-chalcogen cluster SBUs, and 4) ZCOFs based on mixed types of metal-cluster SBUs.

Construction of Zeolite-Like Cluster Organic Frameworks from 3 d-4 d/3 d-3 d Heterometallic Supertetrahedral Secondary Building Units: Syntheses, Structures, and Properties.

Two zeolite-like cluster organic frameworks based on Cd-Cu/Mn-Cu heterometallic supertetrahedral secondary building units have been successfully constructed under solvothermal conditions, namely, Cu[Cd Cu (L) (H O) ](Ac) ⋅DMA⋅3 H O (1), and Cu[Mn Cu (L) (Ac) (H O) ](Ac) ⋅CH CN⋅13 H O (2), where H L=2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol, Ac=CH COO , DMA=N,N'-dimethylacetamide. Single-crystal X-ray structural analysis reveals that both 1 and 2 exhibit 3-dimensional zeolite-like architectures with similar 4-connected components, but possess definitely different topologies of diamondoid (dia) and uncommon lonsdaleite (lon), respectively. 1 and 2 represent the first cases of zeolite-like cluster organic frameworks containing Cd-Cu/Mn-Cu heterometallic supertetrahedral secondary building units.

Cluster Organic Frameworks Constructed from Heterometallic Supertetrahedral Cluster Secondary Building Units.

The two novel cluster organic frameworks based on heterometallic supertetrahedral cluster secondary building units (SBUs) [CdCu(L)(Ac)(HO)](Ac)·7HO (1) and [MnCu(L)(Ac)(HO)]CuCN(Ac)·HO (2), where HL = 2-(hydroxymethyl)-2-(pyridin-4-yl)-1,3-propanediol and Ac = CHCOO, have been prepared under solvothermal conditions. 1 and 2 are the first cases of cluster organic frameworks containing Cd-Cu/Mn-Cu heterometallic supertetrahedral cluster SBUs. Furthermore, 1 and 2 show an integration of magnetic properties and adsorption properties from both the heterometallic cluster secondary building units and the framework in a porous material.

Phosphate removal from water by a novel zeolite/lanthanum hydroxide hybrid material prepared from coal fly ash.

This study was undertaken to investigate the effectiveness of the hybrid adsorbent, which was synthesized from coal fly ash and was composed of lanthanum hydroxide and zeolite (La-ZFA), for phosphate removal from water. Long-term repeated adsorption tests for 30 days showed that the maximum removal capacity of the material reached 66.09 mg P/g.

[Effects of human ERMAP-siRNA on erythroid differentiation of K562 cells induced by Ara-C].

In order to investigate the potential role of human ERMAP gene in erythropoiesis, the ERMAP-dsDNA was designed, ERMAP-shRNA expressing plasmids was constructed, and ERMAP-shRNA/K562 cell was established. Cell morphology, biphenylamine staining, expression of cell surface antigens as well as quantitative level of human ERMAP gene were observed during K562 cells differentiating toward erythroid lineage induced by Ara-C. The results showed that at 72 hours after Ara-C treatment, ERMAP-shRNA/K562 cell size became large with increasing cytoplasm content.