Prevalence of work hour alcohol use and associated factors among psychiatrists in China.

Background: Since 2012, work-hour alcohol use (WHAU) has been prohibited in China. However, there is a lack of national data on WHAU among healthcare workers, including psychiatrists.

Methods: We collected data from psychiatrists in 41 tertiary psychiatric hospitals using an online questionnaire, which included demographics, work-related factors, WHAU, and the Alcohol Use Disorder Identification Test-Consumption (AUDIT-C).

Gender differences in the associations between body mass index, depression, anxiety, and stress among endocrinologists in China.

Background: Depression, anxiety, and stress symptoms have been found to be associated with overweight or obesity, but the gender differences in the associations have not been well-examined. Based on a national sample of endocrinologists in China, we examined such associations with a focus on gender differences.

Methods: Data were collected from endocrinologists in China using an online questionnaire, which included demographic data, body weight, and height.

The Study of Enteromorpha-Based Reinforcing-Type Flame Retardant on Flame Retardancy and Smoke Suppression of EPDM.

Enteromorpha, as a waste from marine pollution, brings great pressure to environmental governance every year, especially for China. Under the premise of a shortage of industrial materials, taking appropriate measures can turn waste into wealth, which will benefit us a lot. In this work, a bio-based reinforcing-type flame retardant based on Enteromorpha is designed.

Application of a high-resolution in vitro human MDR1-MDCK assay and in vivo studies in preclinical species to improve prediction of CNS drug penetration.

P-glycoprotein (P-gp, MDR1) is expressed at the blood-brain barrier (BBB) and restricts penetration of its substrates into the central nervous system (CNS). In vitro MDR1 assays are frequently used to predict the in vivo relevance of MDR1-mediated efflux at the BBB. It has been well established that drug candidates with high MDR1 efflux ratios (ERs) display poor CNS penetration.

Synergistic Fire Hazard Effect of a Multifunctional Flame Retardant in Building Insulation Expandable Polystyrene through a Simple Surface-Coating Method.

This work reports a strategy based on γ-aminopropyltriethoxysilane (KH550) and graphene oxide (GO)-functionalized 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) to fabricate P-N-Si integrated flame retardant [KDOPO-modified GO (DGO)] through mild Mannich and Silanization reactions to overcome the challenge of single gas-phase fire retardancy of DOPO. DGO-based phenolic epoxy resin (DGO/PER) is manufactured and coated on the surface of expandable polystyrene (EPS) foam plates to achieve fire safety, which is used as the thermally insulating external wall in buildings and constructions. The DGO/PER paintcoat imparts high fire safety to the EPS foam plate, exhibiting a high limiting oxygen index value of 29%, and a UL-94 V-0 classification is achieved with only 300 μm of layer thickness compared with the DOPO/PER paintcoat.

In utero and postnatal VX-770 administration rescues multiorgan disease in a ferret model of cystic fibrosis.

Cystic fibrosis (CF) is a multiorgan disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (). In patients with CF, abnormalities initiate in several organs before birth. However, the long-term impact of these in utero pathologies on disease pathophysiology is unclear.

Pharmacokinetic and Drug-Drug Interaction Profiles of the Combination of Tezacaftor/Ivacaftor.

Drug-drug interaction (DDI) studies are described for tezacaftor/ivacaftor, a new cystic fibrosis transmembrane conductance regulator modulator therapy for the treatment of cystic fibrosis. Three phase I DDI studies were conducted in healthy subjects to characterize the DDI profile of tezacaftor/ivacaftor with cytochrome P450 (CYP)3A substrates, CYP3A inhibitors, and a permeability glycoprotein (P-gp) substrate. The effects of steady-state tezacaftor/ivacaftor on the pharmacokinetics (PKs) of digoxin (a P-gp substrate), midazolam, and ethinyl estradiol/norethindrone (CYP3A substrates) were evaluated.

Lubrication and plasticization behavior of large-size micro-spherical structured SiO for natural rubber.

In many rubber dynamic applications such as tires and seals, imparting excellent flex fatigue properties and processing behavior are of prime importance. Research in this direction has been done based on a judicious choice of polymer type or a blend thereof and the compounding ingredients. In this study, the effect of micro-spherical SiO on the flex fatigue properties and processing behavior of natural rubber (NR) is studied.