Discovery of Novel -Aminophenol Derivatives Targeting Lipid Peroxidation with Potent Antiferroptotic Activities.

The concept of ferroptosis inhibition has gained growing recognition as a promising therapeutic strategy for addressing a wide range of diseases. Here, we present the discovery of four series of -aminophenol derivatives as potential ferroptosis inhibitors beginning with the endogenous substance 3-hydroxyanthranilic acid (3-HA) by employing quantum chemistry techniques, in vitro and in vivo assays. Our findings reveal that these -aminophenol derivatives exhibit unique intra-H bond interactions, compelling -amines to achieve enhanced alignment with the aromatic π-system, thereby expanding their activity.

Design, synthesis, and biological evaluation of 2-amino-6-methyl-phenol derivatives targeting lipid peroxidation with potent anti-ferroptotic activities.

The suppression of ferroptosis is emerging as a promising therapeutic strategy for effectively treating a wide range of diseases, including neurodegenerative disorders, organ ischemia-reperfusion injury, and inflammatory conditions. However, the clinical utility of ferroptosis inhibitors is significantly impeded by the limited availability of rational drug designs. In our previous study, we successfully unraveled the efficacy of ferrostatin-1 (Fer-1) attributed to the synergistic effect of its ortho-diamine (-NH) moiety.

Structural Change and Radical Generation of a Cadmium-Based Metal-Organic Framework Induced by an Electric Field.

Herein we report the structural change and radical generation of a cadmium-based metal-organic framework (Cd-MOF) induced by external electric fields. Under a weaker single electric field, different coordination modes of Cd-L lead to 3D → 2D structural change. Under stronger superposed electric fields, Cd-MOF was excited to produce a stable free radical.

Facility-Level Emissions and Synergistic Control of Energy-Related Air Pollutants and Carbon Dioxide in China.

Boilers involve ∼60% of primary energy consumption in China and emit more air pollutants and CO than any other infrastructures. Here, we established a nationwide, facility-level emission data set considering over 185,000 active boilers in China by fusing multiple data sources and jointly using various technical means. The emission uncertainties and spatial allocations were significantly improved.

[FeS-Ag]-Hydrogenase Active-Site-Containing Coordination Polymers and Their Photocatalytic H Evolution Reaction Properties.

Three [FeS-Ag]-hydrogenase active-site-containing coordination polymers (CPs), {[FeS-Ag](4-cpmt)(CO)(ClO)} (), {[FeS-Ag](4-cpmt)(CO)(OTf)(benzene)} (), and {[FeS-Ag](3-cpmt)(CO)(ClO)} (), were obtained by a direct synthesis method from ligands [FeFe](4-cpmt)(CO) [; 4-cpmt = (4-cyanophenyl)methanethiolate] and [FeFe](3-cpmt)(CO) [; 3-cpmt = (3-cyanophenyl)methanethiolate] with silver salts. - represent the first examples of [FeFe]-hydrogenase-based CPs. It was worth noting that the Ag-S bonding between the Ag centers and S atoms of a [FeS] cluster produced a novel [FeS-Ag] ( = 1 or 2) catalytic site in all three polymers.

Non-negligible contributions to human health from increased household air pollution exposure during the COVID-19 lockdown in China.

Background: Ambient and household air pollution are found to lead to premature deaths from all-cause or cause-specific death. The national lockdown measures in China during COVID-19 were found to lead to abrupt changes in ambient surface air quality, but indoor air quality changes were neglected. In this study, we aim to investigate the impacts of lockdown measures on both ambient and household air pollution as well as the short-term health effects of air pollution changes.

Effect of the Coal Preparation Process on Mercury Flows and Emissions in Coal Combustion Systems.

Coal preparation is effective in controlling primary mercury emissions in coal combustion systems; however, the combustion of coal preparation byproducts may cause secondary emissions. The inconsistent coal preparation statistics, unclear mercury distribution characteristics during coal preparation, and limited information regarding the byproduct utilization pathways lead to great uncertainty in the evaluation of the effect of coal preparation in China. This study elucidated the mercury distribution in coal preparation based on the activity levels of 2886 coal preparation plants, coal mercury content database, tested mercury distribution factors of typical plants, and then traced the mercury flows and emissions in the downstream sectors using a cross-industry mercury flow model.