Publications by authors named "Lichun Wei"
Purpose: To explore differences in the effects of total neoadjuvant therapy (TNT) and preoperative concurrent chemoradiation therapy (CRT) on quality of life and functional outcomes in patients with locally advanced rectal cancer.
Methods And Materials: In the study, 591 patients with distal or middle-third, clinical primary tumor stage cT3 to 4 and/or regional lymph node-positive rectal cancer were randomly assigned (1:1) to receive short-term radiation therapy (25 Gy in 5 fractions) followed by 4 cycles of CAPOX (TNT group, n = 297) or standard CRT (50 Gy in 25 fractions concurrently with oral capecitabine) (CRT group, n = 294) before surgery. After a 6-year follow-up, the surviving patients were sent surveys, including the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30, EORTC QLQ-CR29, and Wexner incontinence score questionnaires.
Article Synopsis
- The study aimed to investigate how the quality of multidisciplinary teams (MDTs) affects the survival rates of patients with locally advanced rectal cancer who underwent surgery.
- It analyzed data from the STELLAR trial, revealing that fewer specialized disciplines, infrequent meetings, and lower annual discussion volumes in MDTs were linked to poorer disease-free survival (DFS) and overall survival (OS).
- Patients treated in hospitals with high-quality MDTs demonstrated significantly better 3-year OS compared to those in general quality hospitals, indicating that strong MDT frameworks can enhance patient outcomes.
Article Synopsis
- The study aimed to understand how lateral pelvic lymph node (LPLN) metastasis affects outcomes in patients with locally advanced rectal cancer (LARC) using data from a phase III randomized controlled trial.
- Out of 591 patients, 99 were found to have LPLN metastasis, mainly unilateral; those with LPLN metastasis showed significantly lower three-year disease-free survival, overall survival, and metastasis-free survival compared to those without.
- The findings suggest that LPLN metastasis is an important independent prognostic factor in LARC patients, particularly for those with certain cancer characteristics, highlighting its negative impact on patient outcomes.
Article Synopsis
- The STELLAR II study explores combining short-course radiotherapy with neoadjuvant chemotherapy and immune checkpoint inhibitors (specifically sindilizumab) for patients with locally advanced rectal cancer to improve treatment outcomes.
- The trial involves 588 participants, who will be assigned to either the experimental group (with immunotherapy) or the control group (without immunotherapy) after receiving short-course radiotherapy.
- The study aims to assess the complete remission rate and various secondary health outcomes, utilizing a seamless phase II/III randomized controlled design.
Background: The brachytherapy is an indispensable treatment for gynecological tumors, but the quality and efficiency of brachytherapy training for residents is still unclear.
Methods: An anonymous questionnaire was designed to collect information on gynecological brachytherapy (GBT) training for radiation oncology residents from 28 training bases in China. The questionnaire content was designed based on the principle of competency based medical education (CBME).
Alzheimer's disease (AD) is an age-associated neurodegenerative disease. Recently, studies have demonstrated the potential involvement of microRNA-181c-5p (miR-181c-5p) in AD. However, the mechanism through which miR-181c-5p is responsible for the onset and progression of this disease remains unclear, and our study aimed to explore this problem.
View Article and Find Full Text PDFA platinum-based concurrent chemoradiotherapy (CCRT) is the standard treatment for refractory cervical cancer (CC). However, the recurrence of disease and the occurrence of metastasis remain prevalent. We observed the long-term efficacy and safety of bevacizumab combined with neoadjuvant chemotherapy (NACT) and CCRT in refractory CC.
View Article and Find Full Text PDFObjective: To investigate the correlation between tumor size, tumor location, and prognosis in patients with early-stage endometrial cancer (EC) receiving adjuvant radiotherapy.
Methods: Data of patients who had been treated for stage I-II EC from March 1999 to September 2017 in 13 tertiary hospitals in China was screened. Cox regression analysis was performed to investigate associations between tumor size, tumor location, and other clinical or pathological factors with cancer-specific survival (CSS) and distant metastasis failure-free survival (DMFS).
Background: Endometrial cancer is a prevalent gynecologic malignancy found in postmenopausal women. However, in the last two decades, the incidence of early-stage has doubled in women under 40 years old. This study aimed to investigate the clinical and pathological characteristics and adjuvant therapeutic modalities of both young and not -young patients with early-stage endometrial cancer in China's real world.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on creating a predictive model for the response to neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced cervical cancer using T2-weighted MRI scans and clinical data.
- A total of 138 patients were analyzed, with features extracted from MRI images and clinical information to develop a hybrid model that combined various classification techniques for better prediction accuracy.
- The results showed that the hybrid model achieved an average area under the curve (AUC) of 0.80, significantly outperforming models using only clinical data or image features alone, thus demonstrating its potential for predicting treatment responses.
Article Synopsis
- The study analyzed postoperative radiotherapy practices for early-stage endometrial carcinoma patients across 13 Chinese medical centers between 2003 and 2017.
- A significant trend was observed where vaginal brachytherapy (VBT) became the primary treatment modality for low to intermediate-risk patients, while external beam pelvic radiotherapy (EBRT) continued to be used for high-risk patients.
- The research highlighted variability in VBT dose fractionation schedules and noted a transition from conventional radiotherapy to modern techniques like three-dimensional conformal and intensity-modulated radiotherapy during the study period.
Rationale: Ultrasound-guided brachial plexus block is a common anesthetic procedure used in upper extremity surgery. However, it may not be a suitable option for some patients.
Patient Concerns: A 17-year-old woman with the left palmar schwannoma scheduled for surgical treatment received ultrasound-guided brachial plexus block.
Introduction And Importance: Currently, selective arterial embolization (SAE) has been widely applied for the treatment of many diseases due to its minimal invasiveness. But the complications caused by SAE can be serious.
Case Presentation: Here, we report a case of a patient who experienced bilateral blindness 4 h after selective arterial embolization (SAE).
Article Synopsis
- Trastuzumab-based chemotherapy is the standard first-line treatment for advanced HER2-positive gastric cancer but resistance is a challenge, particularly in cases associated with Epstein-Barr Virus (EBV).
- A 45-year-old man with advanced EBVaGC experienced a partial response after initially failing trastuzumab combined with chemotherapy, leading to successful treatment outcomes after switching to anti-PD-1 therapy (nivolumab).
- Following 30 cycles of postoperative immunotherapy and continuing treatment for new metastasis with toripalimab, the patient achieved complete remission, demonstrating the potential of PD-1 inhibitors in overcoming resistance in advanced gastric cancer.
Objective: To investigate the combined predictive value of the preoperative serum cancer antigen 125 (CA125) level and age at diagnosis among patients with early-stage endometrial cancer (EC) after initial treatment.
Methods: We retrospectively analyzed data from patients with early-stage EC from 1999 to 2015 in multiple institutions in China. All 447 patients received postoperative adjuvant radiotherapy for FIGO 2009 stage I and II EC with complete data on preoperative serum CA125 levels.
The standard of care for locally advanced cervical cancer is concurrent chemoradiotherapy, which is associated with significant toxicity, especially hematologic toxicity. To evaluate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in preventing neutropenia during radical chemoradiotherapy for cervical cancer, 40 patients receiving prophylaxis from February 2018 to July 2019 were randomly divided into two arms in a 1:1 ratio. Patients in the study arm (N = 21) received PEG-rhG-CSF, while patients in the control arm (N = 19) received short-acting rhG-CSF.
View Article and Find Full Text PDFThis study aimed to compare the outcomes of RT modalities among patients who met different HIR criteria based on multicentric real-world data over 15 years. The enrolled patients, who were diagnosed with FIGO I-II EC from 13 medical institutes and treated with hysterectomy and RT, were reclassified into HIR groups according to the criteria of GOG-249, PORTEC-2, and ESTRO-ESMO-ESGO, respectively. The trends in RT modes utilization were reviewed using the Man-Kendall test.
View Article and Find Full Text PDFArticle Synopsis
- * Immunotherapy treatments show promise for patients with specific genetic mutations (dMMR/MSI-H), but combining CRT with PD-1 inhibitors has unclear effectiveness.
- * A specific case demonstrated that a combination of short-course radiotherapy, chemotherapy (XELOX), and the PD-1 inhibitor tislelizumab led to complete response in both the primary tumor and liver metastases, suggesting potential benefits for managing LARC in patients with complex gene mutations.
Background: Patients with locally advanced esophageal cancer with a lesion length greater than 8 cm (LCWEC) are prone to high mortality in a short time due to esophagotracheal fistula (ETF) and esophagoaortic fistula (EAF). We tried to explore a safe salvage surgical method during the perioperative period to maximize the resection of the tumor on the premise of safety and reconstruction of the alimentary tract to avoid early death due to ETF and EAF.
Methods: From December 2007 to November 2018, forty-five LCWEC patients were treated using the modified Wu's esophagectomy.
Objective: This study aimed to investigate the relationship between prognostic and tumor parameters of cervical cancer patients, such as tumor size (TS), tumor volume (TV), and tumor volume reduction rate (TVRR) after external beam radiotherapy.
Methods: A total of 217 patients with advanced cervical cancer, classified as Federation of Gynecology and Obstetrics (FIGO) IIa-IVa, were enrolled in the study. Pre- and mid-RT pelvic magnetic resonance imaging (MRI) were performed twice, during RT and just before brachytherapy.
The present study evaluated the prognosis of directional atherectomy (DA)+drug-coated balloon (DCB) angioplasty for femoropopliteal artery lesions compared with bare nitinol stent (BNS). This retrospective cohort study included patients with femoropopliteal artery lesions who underwent percutaneous endovascular surgery between January 2016 and June 2019. The primary outcome was the primary patency rate after 12, 24, and 36 months; the secondary outcomes comprised incidence of flow-limiting dissections, technical success, limb salvage, and all-cause death.
View Article and Find Full Text PDFObjective: The study aims to investigate if a relationship exists between vaginal doses and vaginal stenosis (VS) using posterior-inferior border of symphysis (PIBS) points and the International Commission on Radiation Units-Rectum (ICRU-R) point evaluation system for definitive radio(chemo)therapy in locally advanced cervical cancer.
Methods And Materials: From a vaginal dose study in China, 351 patients were prospectively assessed. For every reference point of the PIBS system and ICRU-R point was calculated for all BT and summed with EBRT.
Background: This research aimed to provide an overview of the impact of adjuvant vaginal brachytherapy (VBT) and external beam pelvic radiotherapy (EBRT) with or without VBT on survival in stage I to II EC patients in China from a long-term multi-institutional analysis.
Methods: We retrospectively analyzed stage I to II EC patients from 13 institutions treated between 2003 and 2015. All patients underwent surgical staging and received adjuvant RT.
Purpose: To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.
Materials And Methods: Patients with distal or middle-third, clinical primary tumor stage 3-4 and/or regional lymph node-positive rectal cancer were randomly assigned (1:1) to short-term radiotherapy (25 Gy in five fractions over 1 week) followed by four cycles of chemotherapy (total neoadjuvant therapy [TNT]) or chemoradiotherapy (50 Gy in 25 fractions over 5 weeks, concurrently with capecitabine [chemoradiotherapy; CRT]). Total mesorectal excision was undertaken 6-8 weeks after preoperative treatment, with two additional cycles of CAPOX (intravenous oxaliplatin [130 mg/m, once a day] on day 1 and capecitabine [1,000 mg/m, twice a day] from days 1 to 14) in the TNT group and six cycles of CAPOX in the CRT group.
Article Synopsis
- The study focuses on developing a radiomic signature from MRI scans to predict disease-free survival (DFS) in patients with locally advanced cervical cancer who received chemoradiotherapy.
- It involved analyzing MRI data from 263 patients and used statistical methods like LASSO and Cox regression to create a signature highlighting four key features associated with poorer DFS.
- Results showed that this radiomic signature performed better in predicting DFS compared to traditional clinical models, suggesting its potential as a valuable non-invasive prognostic tool for high-risk patients.