Residue Behavior and Risk Assessment of Diazepam and Its Metabolites in Crucian Carp (Carassius auratus) After Oral Administration.

Diazepam (DZP), a benzodiazepine medication, is extensively utilized in both human and veterinary medicine and has been frequently detected in fish populations. The use of DZP-laced bait is identified as a predominant contributor to drug residue contamination in fish. Nonetheless, our understanding of the residue profile of DZP in fish and its potential implications for human health remains constrained.

GWSF-EuSWAP70 gene expression to enhance gray mold resistance in Arabidopsis thaliana.

Background: Eucalyptus, a widely cultivated woody plant, is susceptible to a diverse array of pests and diseases, leading to reduced yields and economic losses. Traditional breeding methods are very time-consuming; therefore, plant genetic engineering has emerged as a promising approach for plant pathogen management. However, the genetic transformation system of eucalyptus is still in its early stages of development, while studies on transgenic eucalyptus and its disease resistance genes are limited.

Time-Frequency Aliased Signal Identification Based on Multimodal Feature Fusion.

The identification of multi-source signals with time-frequency aliasing is a complex problem in wideband signal reception. The traditional method of first separation and identification especially fails due to the significant separation error under underdetermined conditions when the degree of time-frequency aliasing is high. The single-mode recognition method does not need to be separated first.

Lunar rock investigation and tri-aspect characterization of lunar farside regolith by a digital twin.

Yutu-2 rover conducted an exciting expedition on the 41st lunar day to investigate a fin-shaped rock at Longji site (45.44°S, 177.56°E) by extending its locomotion margin on perilous peaks.

Pharmacokinetics, withdrawal period and risk assessment of enrofloxacin in the northern snakehead (Channa argus) following bath administration.

Enrofloxacin (ENR) is widely used in aquaculture practice, but little is known about its pharmacokinetic, withdrawal period and dietary risk in fish via bath administration. The purpose of this study was to provide data support for the use of ENR bath therapy in the northern snakehead (Channa argus). The pilot study was carried out to evaluate the therapy concentrations of ENR in northern snakehead with immersion concentrations ranged from 5 to 40 mg/L for 6 h.

Simultaneous determination of enantiomer residues of metalaxyl and its metabolite metalaxyl acid in animal muscle tissues by chiral liquid chromatography-tandem mass spectrometry.

The toxicity of the two enantiomers of metalaxyl is significantly different and, for food safety concerns, stereoselective analysis of its residues is extremely important in animal muscle tissues. Herein, a simple, sensitive and reproducible method for the simultaneous stereoselective analysis of metalaxyl and its metabolite metalaxyl acid in animal-derived foods has been established based on mixed-mode anion exchange solid phase extraction and chiral liquid chromatography-tandem mass spectrometry. Under the optimized separation and sample pretreatment conditions, good linearity (r > 0.

Notoginsenoside R1 inhibits hepatitis B virus replication by modulating SIRT1 activity.

The hepatitis B virus (HBV) infection remains highly prevalent globally. The present study aimed to explore the possible therapeutic effect of notoginsenoside R1, which has attracted considerable attention due to its diverse pharmacological effects, on HBV infection. The HBV-containing hepatocellular carcinoma cell lines, HepG2 and MHCC97H, were used in this study.

Preclinical characterization of ABI-H2158, an HBV core inhibitor with dual mechanisms of action.

The HBV core protein plays an integral role in multiple steps of the HBV lifecycle. Consequently, HBV core inhibitors interrupt multiple steps of the replication cycle, including blocking pgRNA encapsidation and prematurely disassembling existing nucleocapsids, thereby preventing them from transporting relaxed circular (rcDNA) to the nucleus for conversion to covalently closed circular DNA (cccDNA). ABI-H2158 is an HBV core inhibitor that advanced into Phase 2 clinical trials for the treatment of chronic hepatitis B virus infection (cHBV) but was discontinued due to hepatotoxicity.

Changes in Red Color Sensitivity over the Spawning Cycle of Female Three-spined Stickleback ().

Male red nuptial coloration is a primary mating signal for three-spined sticklebacks (), and the retinae of both sexes are especially sensitive to red during the breeding season. Red sensitivity is an important aspect of female mate choice in this species, but only when they are ready to spawn and not over the entire breeding period. Here, we aimed to determine if the red sensitivity of female sticklebacks change over their repeat spawning cycle.

Investigation on the co-combustion characteristics of multiple biomass and coal under O/CO condition and the interaction between different biomass.

The co-combustion of coal and biomass in O/CO conditions is a promising technology for CO capture and waste disposal. Little attention has been paid to the interaction between different biomass in co-combustion process, which is of great significance to the study of the co-combustion mechanism. The co-combustion behavior of coal and multiple biomass under isothermal conditions was characterized by thermogravimetric method, and the interaction between different biomass was investigated from the perspective of thermogravimetric and proximate analysis.

The toxicokinetics and risk assessment of pyrethroids pesticide in tilapia (Oreochromis mossambicus) upon short-term water exposure.

Pyrethroids pesticides (PPs) are the widely adopted synthetic pesticides for agriculture and fishery. The frequent use of these pesticides leads to the accumulation of residues in the freshwater environments in China, subsequently affecting aquatic organisms and ecosystems. However, there are few reports on the toxicological and risk assessment of aquaculture aquatic products.

Mechanism of One-Step Hydrothermally Synthesized Titanate Catalysts for Ozonation.

A titanate nanotube catalyst for ozonation was synthesized with a simple one-step NaOH hydrothermal treatment without energy-consuming calcination. The synthesized titania catalysts were characterized by X-ray diffraction (XRD), Raman, porosimetry analysis, high-resolution transmission electron microscopy (HR-TEM), Fourier transformed infrared (FTIR), and electron paramagnetic resonance (EPR) analysis. The catalyst treated with a higher concentration of NaOH was found to be more catalytically active for phenol removal due to its higher titanate content that would facilitate more OH groups on its surface.

Hydrogen Evolution from Additive-Free Formic Acid Dehydrogenation Using Weakly Basic Resin-Supported Pd Catalyst.

Hydrogen, as a noncarbon energy source, plays a significant role in future clean energy vectors. However, concerns about the safe storage and transportation of hydrogen gas limit its wide application. Featured with high H volumetric density, nontoxicity, and nonflammability, formic acid (FA) is regarded as one of the most encouraging chemical hydrogen carriers.

Pharmacokinetics and Tissue Residue Profiles of Enrofloxacin in Crucian Carp () Following Single and Multiple Oral Administration.

The pharmacokinetics, tissue distribution, and elimination of enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) were investigated to the crucian carp () after single (20 mg/kg b. w.) and multiple oral administration (20 mg/kg b.

Structural Variations of Metal Oxide-Based Electrocatalysts for Oxygen Evolution Reaction.

Electrocatalytic oxygen evolution reaction (OER), an important electrode reaction in electrocatalytic and photoelectrochemical cells for a carbon-free energy cycle, has attracted considerable attention in the last few years. Metal oxides have been considered as good candidates for electrocatalytic OER because they can be easily synthesized and are relatively stable during the OER process. However, inevitable structural variations still occur to them due to the complex reaction steps and harsh working conditions of OER, thus impending the further insight into the catalytic mechanism and rational design of highly efficient electrocatalysts.

Body Mass Index and Gestational Weight Gain Are Associated with Maternal and Neonatal Outcomes Based on Chinese Women.

The objective of the study is to analyze the association between early pregnancy body mass index (BMI), gestational weight gain (GWG), and maternal and neonatal outcomes. The retrospective cohort study was conducted at Quanzhou First Hospital Affiliated to Fujian Medical University from January 2018 to May 2021, with 552 women enrolled. Women were divided into the underweight group, normal weight group, overweight group, and obese group according to early pregnancy BMI.

LncRNA TTN‑AS1 promotes endometrial cancer by sponging miR‑376a‑3p.

Increasing research has demonstrated that lncRNAs participate in the development of multiple cancer types. However, the role of TTN‑AS1 in endometrial cancer (EC) remains unknown. The present study aimed to explore the function of titin‑antisense RNA1 (TTN‑AS1) in EC progression and the underlying mechanisms.

The in situ redispersion of a PdCu/AC alloy catalyst under a CFClCFCl/H atmosphere: a combination of experimental and DFT study.

A novel CFClCFCl(R113)/H gas treatment process was proposed and successfully applied for the redispersion of a sintered alloy PdCu/AC catalyst. The redispersion process was initiated by the formation of an oxidative PdCuCl intermediate, which can easily migrate to a nearby catalyst surface and then be reduced to smaller PdCu NPs.

Desulfurization Performance and Kinetics of Potassium Hydroxide-Impregnated Char Sorbents for SO Removal from Simulated Flue Gas.

Potassium hydroxide-impregnated char sorbents (KOH/char) prepared via an ultrasonic-assisted method were used for SO removal from flue gas. The desulfurization experiment was analyzed using a fixed-bed reactor under 40-150 °C temperature range, using simulated flue gas. X-ray diffraction (XRD), Fourier-transform infrared spectroscopy, and scanning electron microscopy/energy-dispersive X-ray spectroscopy (SEM/EDS) were used to analyze both the chemical and physical characteristics of the sorbents.

[Climate suitability of Ziziphus mauritiana in the main planting areas of Fujian Province, China].

Taiwan green jujube (Ziziphus mauritiana) is a new fruit variety, with remarkable economic benefit. To achieve high quality and high yield of jujube in Fujian Province, we quantified the climate suitability model parameters of the jujube in main production areas of Fujian, and analyzed climate suitability characteristics and change trend of main production areas, based on the yield and meteorological data, combined with literature and phenological observation data and agricultural climate suitability model. The results showed that the model based on the equal weight summation method had the highest reliability.