[Liver injury and polyserositis as rare side effects of oxcarbazepine].

We report the case of a patient with trigeminal neuralgia who developed cholestatic liver injury with systemic inflammation and polyserositis after starting oxcarbazepine therapy. No other causes could be identified. After discontinuation of the drug, there was a complete remission.

Cystoid macular edema after low-energy femtosecond-assisted cataract surgery.

Purpose: This study aimed to evaluate the occurrence of pseudophakic cystoid macular edema (PCME) post low-energy femtosecond laser-assisted cataract surgery (FLACS) in a high-volume surgical setting.

Methods: The medical records of 242 FLACS patients were retrospectively reviewed. The central subfield macular thickness (CSMT) was measured via optical coherence tomography (OCT) before and 4-6 weeks after surgery, and the results were compared for PCME detection.

Prospective Cytokine Profiling in Aqueous Humor Reveals a Proinflammatory Microenvironment in Highly Dense Nuclear Cataracts.

Purpose: To investigate if the cytokine profile in the aqueous humor (AH) of cataract patients varies according to cataract type and severity.

Methods: This prospective study included 397 eyes of 397 patients (median age, 76 years; range, 30-94 years) who underwent standard small-incision phacoemulsification surgery. Cataracts were graded using the LOCS III system: mild (≤3), moderate (3.

Public health risk communication through the lens of a quarantined community: Insights from a coronavirus hotspot in Germany.

Background: Quarantine is one of the most effective interventions to contain an infectious disease outbreak, yet it is one of the most disruptive. We investigated the quarantine of an entire village to better understand risk communication requirements for groups.

Methods: We conducted a cross-sectional, mixed-methods survey study on a single cohort of adult residents in Neustadt am Rennsteig, Germany, six weeks after the removal of a 14-day mandatory community quarantine.

[Christmas article: Heart rate measurement of a medical student on the day of his first scientific presentation].

In this case report, we used an Apple watch series 6 to monitor the heart rate of a medical student making his first scientific presentation. He was monitored continuously from 7:37 a.m.

Trends and Reported Complications in Ankle Arthroplasty and Ankle Arthrodesis in the State of New York, 2009-2018.

Background: Ankle arthroplasty has emerged as a viable alternative to ankle arthrodesis due in large part to recent advancements in both surgical technique and implant design. This study seeks to document trends of arthroplasty and arthrodesis for ankle osteoarthritis in New York State from 2009-2018 in order to determine if patient demographics play a role in procedure selection and to ascertain the utilization of each procedure and rates of complications.

Methods: Patients 40 years and older from 2009-2018 were identified using and ( and ), () diagnosis and procedure codes for ankle osteoarthritis, ankle arthrodesis, and ankle arthroplasty in the New York statewide planning and research cooperative system database.

Prehospital Release of Patients After Treatment in an Anesthesiologist-Staffed Mobile Emergency Care Unit.

Importance: Prehospital treatment and release of patients may reduce unnecessary transports to the hospital and may improve patient satisfaction. However, the safety of patients should be paramount.

Objective: To determine the extent of unplanned emergency department (ED) contacts, short-term mortality, and diagnostic patterns in patients treated and released by a prehospital anesthesiologist supervising a mobile emergency care unit (MECU).

Production of Functional Plant Legumain Proteases Using the Leishmania tarentolae Expression System.

Plant proteases of the legumain-type are key players in many processes along the plant life cycle. In particular, legumains are especially important in plant programmed cell death and the processing and maturation of seed storage proteins within the vacuole. Plant legumains are therefore synonymously called vacuolar processing enzymes (VPEs).

Epidemiology and Revision Rates of Pediatric ACL Reconstruction in New York State.

Background: There are limited epidemiologic data examining the incidence of pediatric anterior cruciate ligament reconstruction (ACLR) over the past decade.

Purpose: To examine statewide population trends in the incidence of ACLR in a pediatric population.

Study Design: Descriptive epidemiology study.

Calcium-dependent ESCRT recruitment and lysosome exocytosis maintain epithelial integrity during Candida albicans invasion.

Candida albicans is both a commensal and an opportunistic fungal pathogen. Invading hyphae of C. albicans secrete candidalysin, a pore-forming peptide toxin.

Demographic Disparities amongst Patients Receiving Carpal Tunnel Release: A Retrospective Review of 92,921 Patients.

Unlabelled: Despite strong evidence supporting the efficacy of surgical release for carpal tunnel syndrome (CTS), previous studies have suggested that surgery is not performed equally amongst races and sex. The purpose of this study was to investigate potential socioeconomic disparities in the surgical treatment for CTS.

Methods: Adult patients (≥18) were identified in the New York Statewide Planning and Research Cooperative System database from 2011 to 2018 by diagnosis code for CTS.

Insulin induces a progressive increase in the resistance of subcutaneous tissue to fluid flow: Implications for insulin pump therapy.

Aim: To determine the effect of insulin on the resistance of subcutaneous tissue to the flow of infusion fluids.

Materials And Methods: Thirty subjects with type 1 diabetes wore two Accu-Chek Spirit Combo insulin pumps with Accu-Chek FlexLink infusion sets (Roche Diabetes Care, Mannheim, Germany) for 7 days. One pump was filled with insulin aspart (Novo Nordisk, Bagsvaerd, Denmark) and used for continuous subcutaneous insulin infusion (CSII).

Orbital variations as a major driver of climate and biome distribution during the greenhouse to icehouse transition.

Recent studies suggest increasing sensitivity to orbital variations across the Eocene-Oligocene greenhouse to icehouse climate transition. However, climate simulations and paleoenvironmental studies mostly provide snapshots of the past climate, therefore overlooking the role of this short-term variability in driving major environmental changes and possibly biasing model-data comparisons. We address this problem by performing numerical simulations describing the end-members of eccentricity, obliquity, and precession.

The role of risk communication in public health interventions. An analysis of risk communication for a community quarantine in Germany to curb the SARS-CoV-2 pandemic.

Background: Separating ill or possibly infectious people from their healthy community is one of the core principles of non-pharmaceutical interventions. However, there is scarce evidence on how to successfully implement quarantine orders. We investigated a community quarantine for an entire village in Germany (Neustadt am Rennsteig, March 2020) with the aim of better understanding the successful implementation of quarantine measures.

Predicting human touch sensitivity to single atom substitutions in surface monolayers for molecular control in tactile interfaces.

The mechanical stimuli generated as a finger interrogates the physical and chemical features of an object form the basis of fine touch. Haptic devices, which are used to control touch, primarily focus on recreating physical features, but the chemical aspects of fine touch may be harnessed to create richer tactile interfaces and reveal fundamental aspects of tactile perception. To connect tactile perception with molecular structure, we systematically varied silane-derived monolayers deposited onto surfaces smoother than the limits of human perception.

Orbital climate variability on the northeastern Tibetan Plateau across the Eocene-Oligocene transition.

The first major build-up of Antarctic glaciation occurred in two consecutive stages across the Eocene-Oligocene transition (EOT): the EOT-1 cooling event at ~34.1-33.9 Ma and the Oi-1 glaciation event at ~33.

Cenozoic evolution of the steppe-desert biome in Central Asia.

The origins and development of the arid and highly seasonal steppe-desert biome in Central Asia, the largest of its kind in the world, remain largely unconstrained by existing records. It is unclear how Cenozoic climatic, geological, and biological forces, acting at diverse spatial and temporal scales, shaped Central Asian ecosystems through time. Our synthesis shows that the Central Asian steppe-desert has existed since at least Eocene times but experienced no less than two regime shifts, one at the Eocene-Oligocene Transition and one in the mid-Miocene.

Response to Comment on "Revised paleoaltimetry data show low Tibetan Plateau elevation during the Eocene".

Valdes contest our results, suggesting failings in our modeling approach as well as in our comparison with data. Although their comment points to interesting ideas of improvement, we find that their critique reflects an incomplete understanding of our methods and is not supported by the material they provide.

Revised paleoaltimetry data show low Tibetan Plateau elevation during the Eocene.

Paleotopographic reconstructions of the Tibetan Plateau based on stable isotope paleoaltimetry methods conclude that most of the Plateau's current elevation was already reached by the Eocene, ~40 million years ago. However, changes in atmospheric and hydrological dynamics affect oxygen stable isotopes in precipitation and may thus bias such reconstructions. We used an isotope-equipped general circulation model to assess the influence of changing Eocene paleogeography and climate on paleoelevation estimates.

Correction: Eocene metatherians from Anatolia illuminate the assembly of an island fauna during Deep Time.

[This corrects the article DOI: 10.1371/journal.pone.