Publications by authors named "Licheng Gan"
Biomed Pharmacother
October 2024
Article Synopsis
- - The epidermal growth factor receptor (EGFR) is crucial in tumor development and is a key target for treating malignant gliomas, but using small interfering RNA (siRNA) to degrade EGFR mRNA faces challenges like poor targeting and degradation in lysosomes.
- - The research presents a novel siEGFR nanoplex (PEhCv/siEGFR NPs) that combines polyethylene glycol (PEG) and endoplasmic reticulum membrane coatings to improve targeting and uptake in brain gliomas.
- - These nanoplexes showed significantly better siEGFR gene silencing in lab and animal models, potentially leading to more effective nucleic acid-based cancer therapies in the future.
