Expression of SR-BI and LXR in Macrophage Origin Foam Cells of Mouse RAW264.7 Up-regulated by Astragalus Polysaccharide.

Objective: To investigate the influences of polysaccharides (APS) on the expressions of SR-BI(Scavenger receptor-BI) and LXR in RAW264.7 macrophage origin foam cells.

Methods: Mouse RAW264.

The impaired anti-tumoral effect of immune surveillance cells in the immune microenvironment of gastric cancer.

Immune surveillance cells in the tumor microenvironment play an important role in inhibiting tumorigenesis and metastasis, but their anti-tumoral effects are impaired. The anti-tumoral effects of innate immune cells and adaptive immune cells in the immune microenvironment of gastric cancer are also impaired. Their degree of functional impairment is closely related to the prognosis of gastric cancer.

Relationship among the acute toxicity, critical body residue, and bioconcentration of ortho-dinitrobenzene in zebrafish (Danio rerio) based on toxicokinetics.

The internal critical concentration represented by the critical body residue (CBR) is an ideal indicator for reflecting the toxicity of a chemical. Although some authors have realized that the CBR can be calculated from the LC via the bioconcentration factor (BCF), the effects of exposure time and exposure concentration on the relationship between the LC and CBR have not been investigated to date. In this paper, the LC and CBR of ortho-dinitrobenzene in zebrafish were experimentally determined and their relationship was investigated.

Investigation on the relationship between critical body residue and bioconcentration in zebrafish based on bio-uptake kinetics for five nitro-aromatics.

It is well known that the critical body residue (CBR) can be estimated via bioconcentration factor (BCF). However, the relationship between CBR and BCF in zebrafish has not been carried out based on bio-uptake kinetics for nitro-aromatics. In this paper, the time-variable concentrations and CBRs in zebrafish were determined for five nitro substituted benzenes.

Discriminating modes of toxic action in mice using toxicity in BALB/c mouse fibroblast (3T3) cells.

The objective of this study was to determine whether toxicity in mouse fibroblast cells (3T3 cells) could predict toxicity in mice. Synthesized data on toxicity was subjected to regression analysis and it was observed that relationship of toxicities between mice and 3T3 cells was not strong (R = 0.41).