Publications by authors named "Lichan Mao"
Background: Nonalcoholic fatty liver disease (NAFLD), also known as metabolic associated fatty liver disease (MAFLD), is a common liver condition characterized by excessive fat accumulation in the liver which is not caused by alcohol. The main causes of NAFLD are obesity and insulin resistance. Dachaihu decoction (DCHD), a classic formula in traditional Chinese medicine, has been proved to treat NAFLD by targeting different aspects of pathogenesis and is being progressively used in the treatment of NAFLD.
View Article and Find Full Text PDFTetrandrine Attenuates Podocyte Injury by Inhibiting TRPC6-Mediated RhoA/ROCK1 Pathway.
Anal Cell Pathol (Amst)
October 2022
Tetrandrine (Tet), a compound found in a traditional Chinese medicine, presents the protective effect for kidney function. Our study is aimed at clarifying the efficacy and underlying mechanism of Tet on podocyte injury. In this study, podocyte injury was induced in rats with adriamycin (ADR), and MPC5 podocytes were constructed with TRPC6 overexpression.
View Article and Find Full Text PDFBackground: Fangji Huangqi decoction (FHD) is a traditional Chinese medicine formula that has the potential efficacy for nephrotic syndrome (NS) treatment. This study aims to explore the effects and underlying mechanisms of FHD against NS via network pharmacology and in vivo experiments.
Methods: The bioactive compounds and targets of FHD were retrieved from the TCMSP database.
Ibuprofen (IBU) was a widely used NSAID (a type of nonsteroidal anti-inflammatory drug) worldwide, and many drug deliveries had been reported to enhance bioavailability. However, higher bioavailability would increase the danger of renal injury caused by oxidative stress. This study prepared IBU- polysaccharide (IBU-PSP) drug delivery system via mechanochemical method.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between serum uric acid (SUA) levels and the progression of Immunoglobulin A nephropathy (IgAN) in a group of 1,965 patients.
- Elevated SUA levels were found to significantly increase the risk of all-cause mortality and kidney failure over a median follow-up of 7 years, with those in the highest quartile having more than double the risk compared to the lowest quartile.
- Additional factors like mean arterial pressure and specific kidney cell characteristics were noted to influence this association, suggesting that certain patient subgroups may be more vulnerable to the effects of high SUA.