Clinical and immunomodulatory effects of combination immunotherapy with low-dose interleukin 2 and tumor necrosis factor alpha in patients with advanced non-small cell lung cancer: a phase I trial.

Sixteen patients with metastatic non-small cell lung cancer were treated with a combination of simultaneous low-dose interleukin 2 (IL-2) and tumor necrosis factor alpha. The purpose of this phase I dose escalation trial was to assess the clinical toxicities, immunomodulatory effects, and antitumor efficacy of this combination. Patients received a continuous daily i.

Multiple primary cancer in patients with cancer of the head and neck: second cancer of the head and neck, esophagus, and lung.

Squamous cell carcinoma of the head and neck is complicated by a second primary carcinoma of the head and neck, esophagus (the upper aerodigestive tract, or UADT), or lung in 10-40% of patients. Routine panendoscopy will identify a simultaneous second primary in 9-14% of the patients. Metachronous second cancers most often involve the esophagus or lung, whereas synchronous second cancers are more common in the head and neck as occult lesions.

Radio-Resistance of Some Bacterial Pathogens in Soft-Shell Clams ( Mya Arenaria ) and Mussels ( Mytilus Edulis ).

Gamma-irradiation decimal reduction doses were determined for E. coli , Salmonella typhimurium , Shigella flexneri , Strept. faecalis , Staph.

Elevated plasma von Willebrand factor levels and arterial occlusive complications associated with cisplatin-based chemotherapy.

Factor-VIII-related von Willebrand factor (vWF) multimers are synthesized by endothelial cells, and plasma vWF antigen levels are elevated in some disorders associated with endothelial cell perturbation. We studied 13 patients during cisplatin-based combination chemotherapy for squamous cell carcinoma of the head and neck, esophagus, or lung. Before therapy, 3 of the patients had vWF antigen levels that were greater than or equal to 400% of normal; and further elevations occurred during chemotherapy.

Role of computerized cranial tomography in the staging of small cell carcinoma of the lung.

Fifty-five patients with small cell lung cancer underwent computerized cranial tomography (CCT) and a complete neurologic examination as part of their staging work-up. Fifteen patients (27%) had evidence of brain metastases detected by CCT at the time of diagnosis. Eleven of these 15 patients had new focal abnormalities upon neurologic examination.

Acute pneumonitis associated with MOPP chemotherapy of Hodgkin's disease.

A case of a 69-year-old man admitted with procarbazine pneumonitis and a review of the literature are presented. The patient completed a second course of MOPP chemotherapy for Hodgkin's disease three days before admission. He presented with a recent onset of fever, chills, anorexia, and malaise.

Pharmacology, clinical efficacy and adverse effects of vindesine sulfate, a new vinca alkaloid.

Vindesine is a new vinca alkaloid antineoplastic agent derived from vinblastine. However, its antineoplastic spectrum more closely resembles that of vincristine. Clinical studies indicate activity against acute leukemia, lung cancer, carcinoma of the breast, squamous cell carcinoma of the esophagus and head and neck, Hodgkin's disease and non-Hodgkin's lymphomas.

Continuous vindesine infusion in advanced head and neck cancer.

Sixteen patients with advanced squamous cell carcinoma of the head and neck were treated with a 48-hour I.V. vindesine infusion.

Quality Aspects of Commercial Frozen Minced Fish Blocks.

Imported frozen minced Alaska pollock blocks were inferior in flavor and texture when compared to minced blocks prepared from certain species of North Atlantic fish. Organoleptic scores were strongly influenced by the cooking method, that is, baked versus fried. Quality attributes assessed by objective tests (thiobarbituric acid, trimethylamine, dimethylamine, aerobic plate count) generally did not show strong correlation with sensory scores.

Microbiological Quality of Commercial Frozen Minced Fish Blocks.

Two hundred and eight commercial blocks of imported frozen minced fish examined for aerobic plate count, fecal coliforms, and coagulase-positive staphylococci were found to be in compliance with the proposed standards of the International Commission on the Microbiological Specifications for Foods. There was no significant correlation between aerobic plate count (35 C) and certain indicator organisms (coliforms, fecal streptococci, and coagulase-positive staphylococci).

Thermal inactivation of Newcastle disease virus.

The rate of destruction of hemagglutinins and infectivity of Newcastle disease virus was determined over a temperature range of 37.8 to 60 C. From the calculated values of deltaH and deltaS, it was concluded that inactivation of the hemagglutinating activity and viral infectivity was due to protein denaturation.

Effect of temperature on radiosensitivity of Newcastle disease virus.

Newcastle disease virus was irradiated at temperatures ranging from 2.2 to 60 C. An interaction between the thermal and ionizing energy was observed in the temperature region of 49 to 60 C.

Effect of repeated irradiation on various characteristics of Salmonella.

Four Salmonella serotypes which had been subjected to either 15 or 20 cycles of irradiation and subculture were examined for possible changes induced by the treatment. With three serotypes virulence remained unchanged, and with one serotype a reduction had occurred. A few minor changes in the biochemical characteristics occurred in some instances, but with all cultures the serological property was affected to some extent.

Development of radiation resistance in Salmonella cultures.

Cultures of Salmonella subjected to repeated cycles of gamma-irradiation and subculture developed radiation resistance sooner at a low cycling dose ( approximately 1% survival) compared to a high cycling dose ( approximately 0.001% survival). Radioresistant cells in a population of radiosensitive cells of Salmonella newport or S.

Kinetics of the thermal inactivation of type E Clostridium botulinum toxin.

Rate of inactivation curves for the "free" toxin, prototoxin, or activated toxin in crude filtrates of Clostridium botulinum type E were nonlinear, consisting of a fast inactivating rate followed by a slow inactivating rate. Thermodynamic parameters were calculated over a temperature range of 125 to 145 F (51.7 to 62.

Thermal inactivation of type E botulinum toxin.

The theoretical required cooking times for inactivation of type E Clostridium botulinum toxin (5,000 ld(50) mouse units per 0.5 ml) in haddock fillets of various sizes were calculated by graphical integration of the toxin inactivation rate and heat penetration data. The results indicated that normal cooking procedures should suffice to inactivate this amount of toxin.

SOME OBSERVATIONS ON BACTERIAL THERMAL DEATH TIME CURVES.

Thermal death rate data were obtained for spores of Clostridium sporogenes P.A. 3679 and Bacillus subtilis var.

Effect of radiation environment on the thermal resistance of irradiated spores of Bacillus subtilis.

The degree of heat sensitization induced in spores of Bacillus subtilis by irradiation with gamma rays was not changed when irradiation was carried out at low oxygen tension (1 mm of Hg) as compared with irradiation in an air atmosphere. The degree of heat sensitization appeared to be slightly greater at pH 7.0 than at pH 4.