[Adenosine cyclic-3',5'-monophosphate phosphodiesterase in hepatomas with different growth rates].

The cAMP phosphodiesterase activity in mouse hepatomas 46, 61 and 22A is established to be lower than in the normal liver. Sensitivity of enzymes to inhibitors in tumours is also lower. Dibutyryl-cAMP inhibits the growth of hepatoma 46 and leads to an increase in the functional activity of tumour cells.

[Effect of psychotropic preparations on cyclic AMP phosphodiesterase activity in the rat cerebral cortex].

Effect of various psychotropic preparations on cAMP phosphodiesterase was studied. Almost all the psychotropic drugs studied were shown to inhibit the enzymatic activity. Neuroleptics--derivatives of phenothiazine and butyrophene--caused the strongest inhibitory effect.

[Interaction of psychotropic and anticonvulsive drugs].

Experiments on rats of the Wistar strain has shown that preliminary repeated introduction of phenobarbitals and chlordiazepoxide weakens the pharmacological effect of medications, increases the liver weight and the protein content, RNA, R-450 cytochrome, accelerates the oxidation of substrates, but to a higher degree of hexobarbital. Aminazine and mellipramine do not significantly influence these indices changing, however, the affinity of R-450 cytochrome to different substrates and the speed of their oxidation.