Publications by authors named "Libera Monaco"
Objectives: The aim of this study was to describe a colon-specific delivery system based on pectin hydrogels formed by complexation with chitosan.
Methods: Hydrogels were prepared at different weight ratios (4:1, 7:1, 10:1; pectin/chitosan), loaded with vancomycin hydrochloride (2:1, 4:1; polymer/drug weight ratio) and collected by spray-drying. The microspheres obtained were characterized in terms of morphology, swelling behaviour, mucoadhesive properties and drug loading efficiency.