Gonadotropin-releasing hormone-like receptor 2 inversely regulates somatic proteostasis and reproduction in .

The quality control machinery regulates the cellular proteome to ensure proper protein homeostasis (proteostasis). In , quality control networks are downregulated cell-nonautonomously by the gonadal longevity pathway or metabolic signaling at the onset of reproduction. However, how signals are mediated between the gonad and the somatic tissues is not known.