Publications by authors named "Liat Oren-Malek"

Article Synopsis
  • - Factor XI (FXI) deficiency is a genetic bleeding disorder that causes excessive bleeding, particularly during surgeries, and is categorized as severe when FXI levels drop below 15-20 IU/dL.
  • - Patients with very severe FXI deficiency (FXI < 1 IU/dL) may develop inhibitory antibodies following treatments like fresh frozen plasma (FFP), leading to high risks of bleeding that are difficult to control.
  • - A case study of a 17-year-old with very severe FXI deficiency who developed an inhibitor after FFP exposure illustrates the need for careful management and recommends using alternative treatments like recombinant activated factor VII and tranexamic acid for safe surgery outcomes.
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Background: Factor XI (FXI) deficiency is a rare autosomal recessive bleeding disorder. Only scarce publications address its clinical features in children. The increased prevalence of FXI deficiency in Israel enabled data collection for this large multicenter cohort study.

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