Publications by authors named "Liat Ben-Gigi"
Article Synopsis
- Inhibition of gene function is commonly studied using RNA interference, but this method may lead to off-target effects, complicating results.
- Genetic mutation techniques like CRISPR/cas9 show differences from RNA interference, sometimes due to compensatory mechanisms rather than just off-target effects.
- A combined approach using both RNA inhibition and CRISPR/cas9 reveals the critical role of Sema4B in glioma biology, highlighting off-target effects and the importance of specific splice variants for glioma cell growth.
Injury to the CNS induces astrogliosis, an astrocyte-mediated response that has both beneficial and detrimental impacts on surrounding neural and non-neural cells. The precise signaling events underlying astrogliosis are not fully characterized. Here, we show that astrocyte activation was altered and proliferation was reduced in Semaphorin 4B (Sema4B)-deficient mice following injury.
View Article and Find Full Text PDFThe p75 neurotrophin receptor (p75(NTR)) interacts with multiple ligands and coreceptors. It is thought to mediate myelin growth inhibition as part of the Nogo receptor complex, in addition to its other roles. Paradoxically, however, peripheral axons of p75(ExonIII-/-) mutant embryos are severely stunted.
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