[Histopathological study of retrolental membranes secondary to persistent hyperplastic primary vitreous].

Objective: To study the pathological characteristics of retrolental membranes (RLMs) secondary to persistent hyperplastic primary vitreous (PHPV), and to discuss the possible pathogenesis of PHPV.

Methods: Experimental study. Six RLMs obtained from six patients with PHPV during vitrectomy were examined by light microscopy (HE & PAS staining).

Epithelial tumors of the lacrimal gland in the Chinese: a clinicopathologic study of 298 patients.

Objective: To examine the clinicopathologic characteristics and clinical features of epithelial tumors of lacrimal gland in China.

Methods: The retrospective case series study included all 298 patients of epithelial lacrimal gland tumors which had been collected in the ophthalmic pathologic laboratory of the Tongren Hospital Beijing in the study period from 1961 to 2005.

Results: Pleomorphic adenomas were the most common tumors (n = 213 (72%)), followed by adenoid cystic carcinoma (n = 58 (20%)), pleomorphic adenocarcinoma (n = 13 (4%)), primary adenocarcinoma (n = 8 (3%)) and other tumors (n = 6 (2%)).

[Studies on multidrug resistance associated protein in retinoblastoma].

Objective: To detect the expression of P-glycoprotein (P-gp), lung resistance associated protein (LRP) and multidrug resistance associated protein (MRP) in retinoblastoma (Rb), to analyze the relationship between the expression of multidrug resistant (MDR) markers with clinic-pathological factors, the correlations among these three markers, and to study the possible mechanism of multidrug resistance in Rb.

Methods: It was an experimental study. Seventy-five cases of Rb were studied with immunohistochemical methods using antibodies against P-gp, LRP and MRP.

Eyelid neoplasms in the Beijing Tongren Eye Centre between 1997 and 2006.

Background And Objective: To examine the spectrum of eyelid neoplastic specimens obtained at the Beijing Tongren Eye Centre between 1997 and 2006.

Patients And Methods: A total of 2,639 eyelid neoplasms were included in the study.

Results: Of the 2,639 eyelid specimens, 2,276 (86.

[Clinical and pathological analysis of 2639 cases of eyelid tumors].

Objective: To describe the histopathologic spectrum and patient characteristics of eyelid tumors in Beijing Tongren Hospital.

Methods: It was a claims database analysis. A total of 2639 eyelid tumors verified histopathologically from January 1997 to December 2006 were included in the study.

[Study on the risk factors for optic nerve invasion in 381 cases of retinoblastoma].

Objective: To investigate the clinical and pathologic outcomes of a large group of retinoblastoma (RB) cases to ascertain the risk factors of RB optic nerve invasion.

Methods: In this paper, we summarized the clinical and pathologic data of 381 retinoblastoma cases in Beijing Tongren Hospital observed from 1990 to 2002. Statistical analyses were performed on the sex, age, unilateral or bilateral cases, length of symptoms, clinical situation, stage, histological type and the degree of optic nerve invasion.

[Photodynamic therapy of pigmented choroidal melanomas in rabbits using hematoporphyrin monomethyl ether].

Objective: The purpose is to determine the effectiveness of photodynamic therapy of experimental choroidal melanoma in rabbits using hematoporphyrin monomethyl ether (HMME).

Methods: Pigmented choroidal melanomas were established in 46 New Zealand albino rabbit eyes. The animals were treated with daily injection of cyclosporine A.

[The effects of matrine on cell proliferation and telomerase activity in retinoblastoma cells in vitro].

Objective: To evaluate the effects of matrine on cell proliferation and telomerase activity in retinoblastoma cells in vitro.

Methods: HXO-Rb44 cells were treated with 0.1 to 3.

[Clinical and pathological features of 112 cases with ocular adnexal lymphoproliferative lesions].

Objective: To investigate the histopathological classification and clinical features of ocular adnexal lymphoproliferative lesions.

Methods: The clinical, histomorphological and immuno-histochemical features of 112 cases of ocular adnexal lymphoproliferative lesions (116 paraffin specimens) were studied retrospectively. The lesions were classified according to the World Health Organization classification of tumors of haematopoietic and lymphoid tissues (2001).

[Clinical significance of mdm2 and p53 expression in orbital rhabdomyosarcoma].

Objective: To evaluate the role of oncogene mdm2 and p53 in the development of orbital rhabdomyosarcoma (ORMS) and demonstrate the feasibility of mdm2 and p53 as biological characteristic markers and prognostic indicators.

Methods: Immunostainings of mdm2, p53 and Ki-67 antigen were performed on archival paraffin-embedded tissues taken from 31 ORMS patients. In situ hybridization was used to demonstrate the expression of mdm2 and p53 on the mRNA level.

[The study on the correlation between telomerase and histopathologic features of retinoblastoma].

Objective: To investigate the correlation between the expression of human telomerase RNA (hTR), human telomerase reverse transcriptase (hTRT) and the proliferation and differentiation of retinoblastoma (RB).

Methods: In 37 RB specimens, the expression of hTR and hTRT was investigated with the methods of in situ hybridization (ISH). Immunohistochemical method was performed to detect the expression of proliferating cell nuclear antigen (PCNA) in RB.

[Clinical and pathological features of 273 cases of lacrimal epithelial tumors].

Objective: A retrospective study of histopathological and clinical aspects of 261 cases of lacrimal tumors (273 paraffin specimens) from Ophthalmic Pathology Laboratory, Beijing Tongren Hospital (Dec. 1961 to Jun. 2002) was performed to investigate the pathological classification and clinical features of these tumors.

Telomerase expression in sebaceous carcinoma of the eyelid.

Background: In humans telomerase is expressed in most cancers and immortal cell lines, and activation of telomerase may play important roles in tumorigenesis and immortalization. This study was to investigate the roles of telomerase activity (TA) and human telomerase RNA (hTR) in sebaceous carcinoma of the eyelid.

Methods: The telomerase repeated amplification protocol (TRAP) was used to demonstrate telomerase activity in 12 cases of sebaceous carcinoma of the eyelid.

[Correlation of tumor angiogenesis with clinicopathologic prognostic parameters in choroidal melanoma].

Objective: Tumor angiogenesis is an essential step for tumor growth, progression and metastasis. Vascular endothelial growth factor (VEGF) is a mitogen specific for vascular endothelial cells, and plays a key role in tumor angiogenesis. The purpose of the present study was to investigate the expression of VEGF mRNA and VEGF protein in choroidal melanoma and to correlate these factors and the microvessel density (MVD) with the clinicopathologic prognostic features.