Publications by authors named "Liao-Xun Lu"
Soluble CD4 effectively prevents excessive TLR activation of resident macrophages in the onset of sepsis.
Signal Transduct Target Ther
June 2023
Article Synopsis
- T lymphopenia happens during sepsis, making infections worse due to a lack of T cells that help control inflammation.
- Researchers found that a special protein called soluble CD4 (sCD4) interacts with another protein on immune cells called MHC II to help reduce this harmful inflammation.
- This interaction prevents overactivation of other proteins that cause inflammation, suggesting that using sCD4 could be a helpful new way to treat sepsis and control inflammation in the body.