Idiopathic calcinosis of scrotum: A case report and review of the literature.

We report a case of 57-year-old male patient with extensive scrotal idiopathic calcium salt deposits with multiple masses fused into a mass occupying 2/3 of the scrotal area. The scrotal mass was completely removed surgically and the postoperative pathology was consistent with idiopathic calcium deposits in the scrotum. In this article, we report this case of idiopathic calcium salt deposits in the scrotum and review the literature to provide some experience for clinical practitioners.

Correlation analysis between CD133, Klk3 and grhl2 expression and tumor characteristics in prostate cancer.

Prostate cancer is a common clinical disease in men. It is known that prostate cancer ranks 3rd in the incidence of malignant tumors of the male genitourinary system in China, which is able to evaluate the riskiness of life expectancy of male patients. Therefore, we investigated the expression of CD133, recombinant human kallikrein 3 (Klk3), grainy head like 2 (grhl2) in prostate cancer, and correlation with tumor characteristics in the present study.

A novel scaffolding algorithm based on contig error correction and path extension.

The sequence assembly process can be divided into three stages: contigs extension, scaffolding, and gap filling. The scaffolding method is an essential step during the process to infer the direction and sequence relationships between the contigs. However, scaffolding still faces the challenges of uneven sequencing depth, genome repetitive regions, and sequencing errors, which often leads to many false relationships between contigs.

ISEA: Iterative Seed-Extension Algorithm for De Novo Assembly Using Paired-End Information and Insert Size Distribution.

The purpose of de novo assembly is to report more contiguous, complete, and less error prone contigs. Thanks to the advent of the next generation sequencing (NGS) technologies, the cost of producing high depth reads is reduced greatly. However, due to the disadvantages of NGS, de novo assembly has to face the difficulties brought by repeat regions, error rate, and low sequencing coverage in some regions.