Targeting CDK2 Confers Vulnerability to Lenvatinib Via Driving Senescence in Anaplastic Thyroid Cancer.

Anaplastic thyroid cancer (ATC) is the most lethal tumor arising from thyroid follicular epithelium. Lenvatinib is an off-label use option for ATC patients in many countries but an approved prescription in Japan. However, lenvatinib resistance is a substantial clinical challenge.

The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments.

Human RAD52 is a prime target for synthetical lethality approaches to treat cancers with deficiency in homologous recombination. Among multiple cellular roles of RAD52, its functions in homologous recombination repair and protection of stalled replication forks appear to substitute those of the tumor suppressor protein BRCA2. However, the mechanistic details of how RAD52 can substitute BRCA2 functions are only beginning to emerge.

Novel study on the prediction of BI-RADS 4A positive lesions in mammography using deep learning technology and clinical factors.

Background: The classification of Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions in mammography is complicated by subjective interpretations and unclear criteria, which can lead to potential misclassifications and unnecessary biopsies. Thus, more accurate assessment methods need to be developed. This study aimed to improve the classification prediction of BI-RADS 4A positive lesions in mammography by combining deep learning (DL) technology with relevant clinical factors.

Description of a new uniformly brown estuarine moray eel (Anguilliformes, Muraenidae) from the Central Indo-Pacific Ocean.

A new estuarine moray eel, , is described based on 14 specimens from Japan, Taiwan, the Philippines, southern Indonesia, and Fiji. It is a small-bodied, slender, uniformly dark-brown moray separated from congeners within the species complex. The new species can be distinguished from congeners by the anteriorly positioned small eyes (5.

Nuclear Structure of Dripline Nuclei Elucidated through Precision Mass Measurements of ^{23}Si, ^{26}P, ^{27,28}S, and ^{31}Ar.

Using the Bρ-defined isochronous mass spectrometry technique, we report the first determination of the ^{23}Si, ^{26}P, ^{27}S, and ^{31}Ar masses and improve the precision of the ^{28}S mass by a factor of 11. Our measurements confirm that these isotopes are bound and fix the location of the proton dripline in P, S, and Ar. We find that the mirror energy differences of the mirror-nuclei pairs ^{26}P-^{26}Na, ^{27}P-^{27}Mg, ^{27}S-^{27}Na, ^{28}S-^{28}Mg, and ^{31}Ar-^{31}Al deviate significantly from the values predicted assuming mirror symmetry.

Impact of Pre-existing Anti-polyethylene Glycol Antibodies on the Pharmacokinetics and Efficacy of a COVID-19 mRNA Vaccine (Comirnaty) In Vivo.

The presence of anti-polyethylene glycol (anti-PEG) antibodies can hinder the therapeutic efficacy of PEGylated drugs. With the widespread use of a PEGylated coronavirus disease 2019 (COVID-19) messenger RNA vaccine (Comirnaty), the impact of pre-existing anti-PEG antibodies on vaccine potency has become a point of debate. To investigate this, we established mouse models with pre-existing anti-PEG antibodies and divided them into 3 groups: group 1 with anti-PEG immunoglobulin G + immunoglobulin M concentrations of 0.

Long-Range Temporal Correlations in Electroencephalography for Parkinson's Disease Progression.

Background: Patients with Parkinson's disease (PD) present progressive deterioration in both motor and non-motor manifestations. However, the absence of clinical biomarkers for disease progression hinders clinicians from tailoring treatment strategies effectively.

Objectives: To identify electroencephalography (EEG) biomarker that can track disease progression in PD.

Relationship Between Heart Rate and Perceived Stress in Intensive Care Unit Residents: Exploratory Analysis Using Fitbit Data.

Background: Intensive care unit (ICU) residents are exposed to high stress levels due to the intense nature of their work, which can impact their mental health and job performance. Heart rate measured through wearable devices has the potential to provide insights into residents' self-reported stress and aid in developing targeted interventions.

Objective: This exploratory study aims to analyze continuous heart rate data and self-reported stress levels and stressors in ICU residents to examine correlations between physiological responses, stress levels, and daily stressors reported.

Uncovering protein regulation during adventitious root formation in Platycladus orientalis cuttings.

Cell totipotency and pluripotency are the cellular basis for root regeneration in Platycladus orientalis (L.) Franco cuttings, and the regeneration of adventitious roots is a key determinant for improving stem-cutting. However, the cellular basis and physiological regulation of adventitious root formation are still ambiguous.

An AI-driven preoperative radiomic subtype for predicting the prognosis and treatment response of patients with papillary thyroid carcinoma.

Purpose: 8-28% of Papillary thyroid carcinoma (PTC) experience recurrence, complicating risk stratification and treatment. We previously identified an inflammatory molecular subtype of PTC associated with poor prognosis. Based on this subtype, we aimed to develop and validate a noninvasive radiomic signature to predict prognosis and treatment response in PTC patients.

Greatly Enhanced Oxygen Reduction Reaction in Anion Exchange Membrane Fuel Cell and Zn-Air Battery via Hole Inner Edge Reconstruction of 2D Pd Nanomesh.

Platinum group metals (PGM) have yet to be the most active catalysts in various sustainable energy reactions. Their high cost, however, has made maximizing the activity and minimizing the dosage become an urgent priority for the practical applications of emerging technologies. Herein, a novel 2D Pd nanomesh structure possessing hole inner reconstructed edges (HIER) with exposed high energy facets and overstretched lattice parameters is fabricated through a facile room-temperature reduction method at gram-scale yields.

Techniques and outcomes of atrial fibrillation ablation in patients with persistent left superior vena cava.

Objectives: To investigate tailored approaches, techniques, and outcomes of catheter ablation in patients with persistent left superior vena cava (PLSVC) undergoing atrial fibrillation (AF) ablation.

Background: PLSVC presents unique challenges for AF ablation due to its potential as an arrhythmogenic source and the complex anatomical variations it introduces.

Methods: The retrospective cohort included 16 patients with PLSVC that underwent 21 AF ablation procedures between August 1, 2008, and February 14, 2024, at the Hospital of the University of Pennsylvania.

Development and validation of a dynamic nomogram for short-term survival in acute heart failure patients with acute kidney injury upon ICU admission.

Objective: The objective of this study is to develop and validate an effective prognostic nomogram for predicting the short-term survival rate of patients with acute heart failure (AHF) complicated by acute kidney injury (AKI) who are admitted to the intensive care unit (ICU).

Patients And Methods: We conducted an analysis of data from patients of AHF with AKI spanning the period from 2008 to 2019, utilizing the MIMIC-IV database. Patients were randomly divided into training and validation sets.

Novel intranasal phage-CaEDTA-ceftazidime/avibactam triple combination therapy demonstrates remarkable efficacy in treating Pseudomonas aeruginosa lung infection.

Given the rise of multidrug-resistant (MDR) Pseudomonas aeruginosa infections, alternative treatments are needed. Anti-pseudomonal phage therapy shows promise, but its clinical application is limited due to the development of resistance and a lack of biofilm penetration. Recently, adjuvants like CaEDTA have shown the ability to enhance the effectiveness of combined antimicrobial agents.