[Clinical analysis on 18 cases of adenoid cystic carcinoma of nasal cavity and sinuses].

Objective: To explore the clinical characteristics and treatment effect of adenoid cystic carcinoma in nasal cavity and sinuses.

Method: Sixteen of all 18 cases of adenoid cystic carcinoma of nasal cavity and sinuses were performed operation and radiotherapy. Other 2 cases were performed radiotherapy.

[Clinical significance of MRP8 and cypA expression in laryngeal squamous cell carcinoma tissues].

Objective: To study differential expression of MRP8, CypA protein in the patients of laryngeal squamous cell carcinoma (LSCC) and the relationship in the development of LSCC.

Method: Immunohistochemistry was used to detect the expression of MRP8,CypA protein in LSCC tissues of 41 cases and matched paraneoplastic normal tissues of 41 cases,with results compared to the clinical data to determine significance.

Result: The expression of MRP8, CypA protein in carcinoma and normal tissues and composition of different positive grades were in statistical significance (P < 0.

[Effects of celecoxib combined with radiotherapy on apoptosis of CNE-2Z cell lines].

Objective: To investigate the effects of celecoxib combined with radiotherapy on apoptosis of CNE-2Z cell lines and the potential mechanisms.

Methods: Four groups were used, a control, celecoxib (25 micromol/L celecoxib), irradiation (8 Gy X ray) and celecoxib plus irradiation. The radiosensitising effect was detected by clone formation experiment.

[Clinical analysis on 14 cases with malignant melanoma in nasal cavity and sinus].

Objective: To investigate the effect of treatment on malignant melanoma in nasal cavity and paranasal sinus.

Method: Fourteen patients with malignant melanoma in nasal cavity and paranasal sinus were retrospectively analyzed from 1995 to 2002, including clinical presentation, diagnosis, treatment and follow-up data.

Result: Thirteen patients were followed up, the survival rates of 3 and 5 years were 42.

[Effect of adenoidectomy on pediatric chronic rhinosinusitis].

Objective: To explore the effect of adenoidectomy on pediatric chronic rhinosinusitis.

Method: A total of 51 pediatric patients with chronic rhinosinusitis were included in this study. There were 17 cases underwent adenoidectomy, 12 cases underwent endoscopic sinus surgery,and 22 cases underwent both adenoidectomy and endoscopic sinus surgery.

[Identification of tumor-associated proteins in laryngeal squamous cell carcinoma by proteomics].

Objective: To establish two-dimensional electrophoresis profiles from human laryngeal squamous cell carcinoma tissue and paired normal tumor-adjacent mucosa epithelia tissue, and to identify differential expression proteins.

Methods: The total proteins of human laryngeal squamous carcinoma tissue and paired normal tumor-adjacent mucosa epithelia tissue were separated by immobilized pH gradient-based two-dimensional gel electrophoresis (2-DE). The differential expression proteins were analyzed using image analysis software, then identified using mass spectrometry and database searching.

[Nasopharyngeal carcinoma and cervical masses].

Objective: To study the clinical characteristic of cervical metastatic lymph nodes in patients with nasopharyngeal carcinoma (NPC) and the relation between NPC and cervical masses.

Method: The clinical material of 246 cases with NPC was analyzed retrospectively.

Result: One hundred and eighty-three of 246 cases suffered from cervical masses and 101 cases began with them.

[Surgical management of carcinoma of the hypopharynx and cervical esophagus].

Objective: To report our experience in reconstructing hypopharynx and cervical esophagus with four kinds of operations.

Method: Twenty one patients underwent reconstruction of the hypopharyngeal and cervical esophagus defect using contralateral hemilaryngeal mucosa flap, pectoralis major myocutaneous flap, forearm free flap and jejunal free flap.

Result: All of cases were successful.

[Hypopharynx reconstruction of defects after operation on advanced pyriform sinus cancer with remaining laryngeal mucosa flap and pectoralis major myocutaneous flap].

Objective: To explore the outcome of hypopharynx reconstruction by using remaining laryngeal mucosa flap and pectoralis major myocutaneous flap in advanced pyriform sinus cancer.

Methods: Twelve patients with pyriform sinus cancers underwent hemilaryngectomy and partial pharyngectomy, two patients underwent cervical esophagectomy at the same time. The defects were reconstructed by remaining laryngeal mucosa flap.

[Analysis on clinical and immunohistochemical characteristics of primary extranodular non-Hodgkin's lymphoma in otolaryngol head and neck].

Objective: To study the characteristic of clinical manifestation and cell immunophenotype in cases with primary extra-nodular non-Hodgkin's lymphoma (PE-NHL) in otolaryngol head and neck for early diagnosis and treatment.

Method: Clinical manifestation of one hundred and fifty five patients with PE-NHL in otolaryngol head and neck from 1991 to 2000 were analyzed and restudied by pathological sections with immunohistochemical technology.

Result: The age of twenty six to fifty years old was the most common age range in the group of patients with PE-NHL.

[A study on the application of Nickle-Titanium alloys stent for prevention and treatment tracheostomal stenosis after total laryngectomy].

Objective: To evaluate the effect of Nickle-Titanium alloys annular stent to prevent and treatment tracheostomal stenosis after total laryngectomy.

Method: The stent was used following total laryngectomy and after total laryngectomy.

Result: Long stent was implanted in 2 cases following total laryngectomy and in 1 cases after total laryngectomy, Which resulted in widening stenosis and relieving obstruction of airway.

[Experimental and clinical study on the chemosensitivity assay in vitro for head and neck tumor by AgNOR methods].

Objective: To evaluate in vitro chemosensitivity of head and neck tumor to eight kinds of antineoplastic drugs by AgNOR technique.

Method: Fifty-nine cases' fresh specimens were obtained from head and neck tumors. We severed tumor tissue with simple mechanical separation method.