Publications by authors named "Lianzhao Du"
Coronaviruses have caused three major endemics in the past two decades. Alarmingly, recent identification of novel zoonotic coronaviruses that caused human infections suggests the risk of future coronavirus outbreak caused by spillover infection from animal reservoirs remains high. Therefore, development of novel therapeutic options with broad-spectrum anti-coronavirus activities are urgently needed.
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- SARS-CoV-2 variant JN.1, featuring a mutation L455S, has surpassed earlier variants, becoming the dominant strain due to its higher infectivity compared to BA.2.86.
- The increased infectivity of JN.1 is linked to improved entry efficiency and spike protein cleavage, aided by the L455S mutation altering how the spike protein binds to ACE2 receptors.
- Research also evaluates the distinct virological traits between JN.1 and other Omicron sublineages, enhancing our understanding of their transmissibility and immune response behaviors.