Publications by authors named "Lianyu Lin"
Background: To evaluate the correlation between atrial fibrillation (AF) burden and two-dimensional LA (left atrium) longitudinal reservoir strain (LARS) to explore the potential clinical utility of this novel parameter in patients with AF.
Methods: This cross-sectional study was conducted at the cardiac electrophysiology clinic of a tertiary centre by consecutively enrolling patients with non-valvular AF. The AF burden was evaluated using 14-day patch-based electrocardiography and defined as the percentage of time spent in AF during a 14-day monitoring period.
Extracorporeal membrane oxygenation (ECMO) provides critical cardiac support, but predicting outcomes remains a challenge. We enrolled 1,748 adult venoarterial (VA)-ECMO patients at the National Taiwan University Hospital between 2010 and 2021. The overall mortality rate was 68.
View Article and Find Full Text PDFBackground: The marine crustacean Oratosquilla oratoria is economically significant in seafood and aquaculture industries. However, the lack of high-quality genome assembly has hindered our understanding of O. oratoria, particularly the mechanisms underlying its developed visual system.
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- Edoxaban, a non-vitamin K oral anticoagulant, is approved for stroke prevention in atrial fibrillation (AF) patients in many Asian countries, but its long-term effectiveness and safety had limited data in Taiwan prior to this study.
- The Global ETNA-AF registry analyzed two-year outcomes in Taiwan and three other Asian countries, revealing that edoxaban users in Taiwan were generally older with lower kidney function but showed comparable low rates of clinical events across regions.
- The study concluded that despite some variations in patient characteristics, the low rates of cardiovascular death and major bleeding events indicate that edoxaban is effective and safe for routine clinical use among AF patients in Taiwan and other Asian countries.
Comparative analysis of mineralocorticoid receptor antagonists and renin-angiotensin system inhibitors/angiotensin receptor neprilysin inhibitor in heart failure with mildly reduced ejection fraction.
Front Pharmacol
December 2024
Introduction: To clarify the efficacy of mineralocorticoid receptor antagonists (MRA) and renin-angiotensin system inhibitors/angiotensin receptor neprilysin inhibitors (RASI/ARNI) in heart failure with mildly reduced ejection fraction (HFmrEF).
Methods: This study assessed the association between these medications and outcomes in HFmrEF using data from the National Taiwan University Hospital-integrated Medical Database. The primary outcome was cardiovascular mortality/heart failure hospitalization (HHF).
Article Synopsis
- Stereotactic arrhythmia radioablation (STAR) has shown effectiveness for treating refractory ventricular tachyarrhythmia (VT), with a focus on a Taiwanese patient group.
- The study involved 11 patients, using advanced imaging techniques to treat VT with a single radiation dose, resulting in a significant 88% reduction in VT episodes within the first six months post-treatment.
- Despite initial success, many patients experienced late VT recurrence, with a one-year survival rate of 83%, leading to some requiring additional treatments such as heart transplants or HeartMate III implantation.
Background: Clinical and experimental evidence have demonstrated the protective benefits of colchicine in acute myocardial infarction (AMI) through its potential anti-inflammatory effect. However, investigations on the Asian population are limited.
Methods: This retrospective longitudinal cohort study used electronic medical records from a tertiary medical center in Taiwan.
Background: The impact of obesity on the prognosis of patients receiving venoarterial extracorporeal membrane oxygenation remains unclear. This study examines the association between body mass index and in-hospital mortality among patients on venoarterial extracorporeal membrane oxygenation support.
Methods: This retrospective study enrolled adult patients who received venoarterial extracorporeal membrane oxygenation support, which included extracorporeal cardiopulmonary resuscitation, at National Taiwan University Hospital between 2010 and 2021.
Background: The recurrence rate of strokes associated with atrial fibrillation (AF) can be substantially reduced through the administration of oral anticoagulants. However, previous studies have not demonstrated a clear benefit from the universal application of oral anticoagulants in patients with embolic stroke of undetermined source. Timely detection of AF remains a challenge in patients with stroke.
View Article and Find Full Text PDFBackground: Previous studies have shown associations between glycemic variability (GV) and cardiovascular outcomes in patients with type 2 diabetes. However, the impact of GV on outcomes in patients with heart failure with preserved ejection fraction (HFpEF) has not been investigated.
Method: Between 2014 and 2019, we conducted a retrospective cohort analysis using the electronic medical records of a tertiary medical center in Taiwan.
Photodependent processes, including circadian rhythm, autophagy, ubiquitination, neddylation/deneddylation, and metabolite biosynthesis, profoundly influence microbial pathogenesis. Although a photomorphogenesis signalosome (COP9/CSN) has been identified, the mechanism by which this large complex contributes to the pathophysiological processes in filamentous fungi remains unclear. Here, we identified eight CSN complex subunits in the rice blast fungus and functionally characterized the translocon subunits containing a nuclear export or localization signal (NES/NLS).
View Article and Find Full Text PDFIsw2 proteins, ubiquitous across eukaryotes, exhibit a propensity for DNA binding and exert dynamic influences on local chromosome condensation in an ATP-dependent fashion, thereby modulating the accessibility of neighboring genes to transcriptional machinery. Here, we report the deletion of a putative MoISW2 gene, yielding substantial ramifications on plant pathogenicity. Subsequent gene complementation and chromatin immunoprecipitation sequencing (ChIP-seq) analyses were conducted to delineate binding sites.
View Article and Find Full Text PDFObjectives: To delineate the effects of exposure to air pollution on the risk of venous thromboembolism (VTE).
Background: The association between air pollution and arterial occlusive diseases has been well reported in the literature. VTE is the third most common acute cardiovascular syndrome; however, its relationship with exposure to air pollution has been controversial.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase-4 inhibitors (DPP4i) are important second-line treatments for patients with type 2 diabetes mellitus (T2DM). Patients taking SGLT2i have favorable cardiovascular outcomes via various mechanisms, including autonomic nervous system (ANS) modulation. This study aimed to use neuro-electrocardiography (neuECG) to test the effects of SGLT2i or DPP4i on the ANS.
View Article and Find Full Text PDFObjective: To assess the effects of colchicine, which has been shown to reduce the risks of coronary artery disease but scarcely studied in peripheral artery disease (PAD), on major adverse limb events (MALE) in patients with PAD.
Methods: This is a retrospective study based on a nationwide database. Patients who were diagnosed with PAD between 2010 and 2020 and prescribed with colchicine after the diagnosis of PAD were identified.
Background: Several studies suggest an "obesity paradox," associating obesity with better cardiovascular outcomes in patients with type 2 diabetes mellitus (DM) or aortic stenosis (AS) compared to normal or underweight individuals. This study explores the impact of body mass index (BMI) on diabetic patients with AS.
Methods: Between 2014 and 2019, patients with DM who underwent echocardiography were analyzed.
Sex-specific associations between prolonged serum uric acid levels and risk of major adverse cardiovascular events.
Int J Cardiol Cardiovasc Risk Prev
September 2024
Background: While hyperuricemia has been correlated with cardiovascular (CV) diseases, further evidence is required to evaluate the implications of stable serum uric acid (sUA) levels, especially concerning low sUA. This study aimed to investigate prolonged stable sUA levels and CV events/mortality.
Methods: We conducted a retrospective cohort study at a medical center using electronic medical records linked with the national claims database.
Aim: Glucagon-like peptide 1 receptor agonists (GLP1RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) are both recommended for patients with diabetes, yet their effects on the development or progression of diabetic retinopathy (DR) are largely unknown.
Methods: In this retrospective cohort study, data were collected from a nationwide database. Patients with diabetes who initiated treatment with a GLP1RA or SGLT2i between 1 May 2016 and 31 December 2017, were identified.
Article Synopsis
- Subclinical atrial fibrillation (AF) increases risks of developing clinical AF, stroke, and cardiovascular death; researchers aimed to test if closed loop stimulation (CLS) could reduce atrial high-rate episodes (AHREs) in pacemaker patients compared to conventional dual-chamber rate-adaptive pacing (DDDR).
- A study with 1,210 patients showed that those using CLS had a lower incidence of the primary endpoint (first AHRE lasting ≥6 min, stroke, or TIA) compared to DDDR over a 3-year period, particularly effective in patients without atrioventricular block or AF history.
- The findings suggest that dual-chamber CLS significantly reduces AHRE occurrence, highlighting its potential benefits for patients
Background: Diastolic dysfunction and alterations in cardiac geometry are early indicators of diabetic cardiomyopathy. However, the association between cardiac changes across the glucose continuum and the contribution of epicardial adipose tissue (EAT) to these changes has not yet been investigated.
Purpose: In this study, we aim to investigated the EAT on cardiac diastolic function and structural alterations along the diabetic continuum using cardiac magnetic resonance imaging (CMRI).
Background: While current guidelines recommend amiodarone and dronedarone for rhythm control in patients with atrial fibrillation (AF) and coronary artery disease (CAD), there was no comparative study of antiarrhythmic drugs (AADs) on the cardiovascular outcomes in general practice.
Methods: This study included patients with AF and CAD who received their first prescription of amiodarone, class Ic AADs (flecainide, propafenone), dronedarone or sotalol between January 2016 and December 2020. The primary outcome was a composite of hospitalization for heart failure (HHF), stroke, acute myocardial infarction (AMI), and cardiovascular death.
The left ventricular global longitudinal strain (LVGLS) is a crucial prognostic indicator. However, inconsistencies in measurements due to the speckle tracking algorithm and manual adjustments have hindered its standardization and democratization. To solve this issue, we proposed a fully automated strain measurement by artificial intelligence-assisted LV segmentation contours.
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- Exercise intolerance is a common issue for patients with atrial fibrillation (AF), and this study sought to identify echocardiographic markers that could predict their exercise capacity.
- The study involved 188 patients with AF who underwent echocardiography and cardiopulmonary exercise testing, finding that 71.2% had impaired exercise capacity, with specific echocardiographic features linked to this decline.
- The left atrial to left ventricular end-diastolic diameter (LA/LVEDD) ratio emerged as a significant predictor of exercise capacity, suggesting its potential importance for patient management, although further research is needed.
Objective: Individuals with hyperthyroidism are at an increased risk of atrial fibrillation (AF), but the association between autoantibodies and AF or cardiovascular mortality in individuals who have returned to normal thyroid function remains unclear.
Methods: The study utilized electronic medical records from National Taiwan University Hospital between 2000 and 2022. Each hyperthyroidism patient had at least 1 thyrotropin-binding inhibiting immunoglobulin (TBII) measurement.