Publications by authors named "Lianyan Yan"
Exposure to metals has been related to alterations in leukocyte telomere length (LTL), an aging marker. However, the evidence regarding this relationship in children and adolescents, as well as the underlying mechanisms, remains unclear. Therefore, we aimed to explore the individual and mixture effects of metals on LTL in children and adolescents and to assess the mediating role of thyroid hormones and the modifying effect of a healthy lifestyle.
View Article and Find Full Text PDFStudy Question: Are reproductive factors associated with biological aging, and does biological aging mediate the associations of reproductive factors with premature mortality?
Summary Answer: Multiple reproductive factors are related to phenotypic age acceleration (PhenoAge-Accel), while adherence to a healthy lifestyle mitigates these harmful effects; PhenoAge-Accel mediated the associations between reproductive factors and premature mortality.
What Is Known Already: Accelerated aging is a key contributor to mortality, but knowledge about the effect of reproductive factors on aging is limited.
Study Design, Size, Duration: This prospective cohort study included 223 729 women aged 40-69 years from the UK biobank in 2006-2010 and followed up until 12 November 2021.
Article Synopsis
- This study investigates how body size in childhood and adulthood, as well as changes between the two, relate to the length of leucocyte telomeres (LTL) in adults.
- Findings show that individuals who were overweight as children or adults generally had shorter LTL, indicating potential negative health implications.
- Importantly, if a child with a plumper body size reaches a normal weight in adulthood, the detrimental impact on LTL appears to be mitigated.
Background: Previous studies have linked single metal to hemoglobin levels in children and adolescents; however, studies with regards to metal mixtures are still limited.
Objective: We aimed to investigate the associations of single metal and metal mixtures with hemoglobin levels in children and adolescents.
Methods: We conducted a cross-sectional study of 2064 children and adolescents aged 6 to 19 years in Liuzhou, China in 2018.