PRP from Personal Blood Relieves Joint Fluid-Inducing Synovial Injury through NF-B Pathway and Mitochondrial Apoptosis in Human Synovial Fibroblast Cells.

Background: Platelet-rich plasma (PRP) therapy is a new kind of biological therapy to retune the plasma concentrator into the patient's body for the treatment of osteoarthritis diseases. The present research aimsed to confirm the treatment effects of PRP against osteoarthritis injury and elucidate its potential mechanism via constructing a kind of cellular injury model of human synovial fibroblast cells (HSF cells) induced by synovial fluid from osteoarthritis patients.

Materials And Methods: HSF cells wereas firstly treated with the different doses of synovial fluid from osteoarthritis patients, and evaluated for the cellular injury via cell morphology and MTT assay.

Multicentric epithelioid hemangioendothelioma involving the same lower extremity: a case report and review of literature.

Epithelioid hemangioendothelioma (EH) is an uncommon low-grade malignant soft-tissue tumor; no case has been previously reported where multicentric epithelioid hemangioendothelioma occurred in the same lower extremity at different sites. We report a case involving the common peroneal nerve and subsequently the long bone and the short bones of the same lower extremity, and also review the literature. After establishing case of several lesions, we reviewed the histopathology properly and followed up the patient for a long time with serial whole body assessment to pick up any subsequent lesions.