Publications by authors named "Liansheng Jiang"

Article Synopsis
  • A novel LC-MS/MS method was developed to quickly and accurately measure 23 tyrosine kinase inhibitors (TKIs) in plasma from cancer patients receiving anlotinib (ANL) treatment.
  • The study involved 55 patients, collecting plasma samples to analyze the relationship between ANL trough concentrations and reported toxicities.
  • Results showed a significant correlation between higher ANL levels and increased toxicity, with a predictive threshold identified, alongside low platelet counts serving as additional risk factors for severe side effects.
View Article and Find Full Text PDF

Background: A wave of the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has rapidly spread in Shanghai, China. Hematological abnormalities have been reported in coronavirus disease 2019 (COVID-19) patients; however, the difference in hematological parameters between COVID-19 patients with fever and patients who are febrile from other causes remains unexplored.

Methods: This retrospective cohort study enrolled 663 SARS-CoV-2 positive patients identified by RT-PCR.

View Article and Find Full Text PDF

Introduction: Pre-eclampsia (PE) is a common and severe obstetric complication. MicroRNAs (miRs) have emerged as molecules that are associated with the disease.

Methods: Quantitative reverse transcription PCR (RT-qPCR) was used for serum miR-520g characterization from 19 severe pre-eclamptic and 19 normal pregnancies.

View Article and Find Full Text PDF

Objective: To investigate whether serum levels of 19 eicosanoids are associated with pre-eclampsia.

Methods: A case-control study was performed using data for pregnant women with pre-eclampsia, normotensive pregnant women, and nonpregnant women, for all of whom serum samples had been collected at a hospital in Shanghai, China, between December 2012 and December 2013. Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure the serum levels of 19 eicosanoids.

View Article and Find Full Text PDF

To identify the specific serum preeclampsia (PE)-related biomarkers, 10 microRNAs (miRNAs) were selected based on their reported aberrant (4 upregulated and 6 downregulated) expression in PE placenta. A total of 1,035 pregnant patients were enrolled. Finally, 32 pregnancies with PE and 32 healthy pregnancies were incorporated in the study.

View Article and Find Full Text PDF

The aim of this study was to examine the consistency of ultra performance liquid chromatography-tandem mass spectrometry (UPLC-TMS) in detecting the levels of para-arachidonic acids (PAAs) among differently processed plasma/serum samples. Ethylenediaminetetraacetic acid (EDTA)-K2, sodium citrate, heparin lithium, coagulant/separation gel, and coagulant-free vacuum blood-sampling tubes were used to collect the fasting blood samples from 15 volunteers. All blood samples were subjected to solid-phase extraction using an Oasis HLB μElution 96-well plate, and UPLC-TMS was used to detect 19 types of PAAs in the blood samples.

View Article and Find Full Text PDF

Viscosities of aqueous solutions of five polyethylene oxide (PEO) samples with molar masses from 1.5 x 10(5) to 1.0 x 10(6) were carefully measured in a polytetrafluoroethylene (PTFE) capillary Ubbelohde viscometer in the concentration range from dilute down to extremely dilute concentration regions and compared with those of the same sample obtained from a glass capillary viscometer.

View Article and Find Full Text PDF