Publications by authors named "Lianqun Du"
Article Synopsis
- Organophosphate compounds (OPs) rapidly inhibit the enzyme acetylcholinesterase (AChE), leading to severe nervous system damage and potentially death, complicating rescue efforts after exposure.
- Researchers developed a biomimetic nanoparticle called 'Nanocleaner,' which utilizes a modified red blood cell membrane and incorporates an enzyme (organophosphorus hydrolase) to target and degrade OPs in the bloodstream.
- In experiments, Nanocleaner showed significant protective effects against OP-induced toxicities, restoring AChE activity and improving survival rates in mice exposed to lethal doses of OPs, highlighting its potential for clinical use in detoxification.
Here, we explored the role of Prolyl 4-Hydroxylase Subunit Alpha 3 (P4HA3), the most recently identified member of the prolyl-4-hydroxylase (P4H) family, in head and neck squamous cell carcinoma (HNSCC) progression. P4HA3 is upregulated during cancer progression; however, its specific role in HNSCC progression remains elusive. Thus, this study aimed to elucidate the regulatory function of P4HA3 in HNSCC development and progression and to describe the underlying mechanisms.
View Article and Find Full Text PDFA novel yeast-based biosensor for the quick determination of Deoxynivalenol.
Anal Chim Acta
August 2024
Mycotoxins are commonly found in food materials and severely threaten human health. Antibodies play a key role as a part of immunological techniques in detecting mycotoxins. Therefore, highly specific antibodies and detection techniques against mycotoxins need to be developed for advancements in medical research.
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- Circadian rhythms help our bodies stay healthy by keeping things like sleep and metabolism on a schedule.
- When these rhythms get messed up, it can lead to health problems like issues with how our immune system works and how we think.
- In a study with mice, changing their light and dark cycles messed up their body clocks, which affected their blood and bone marrow health. This shows that having a regular schedule is important for keeping our bodies functioning well.
This study aimed to investigate the molecular mechanism of triptolide in the treatment of oral squamous cell carcinoma (OSCC) via network pharmacology and experimental validation. The network pharmacological method was used to predict the key targets, detect the signal pathways for the treatment of OSCC, and screen the critical components and targets for molecular docking. Predicted targets were validated in cellular and xenograft mouse model.
View Article and Find Full Text PDFBacteria-infected skin wounds caused by external injuries remain a serious challenge to the whole society. Wound healing dressings, with excellent antibacterial activities and potent regeneration capability, are increasingly needed clinically. Here, we reported a novel functional microneedle (MN) array comprising methacrylated hyaluronic acid (MeHA) embedded with pH-responsive functionalized zeolitic imidazolate framework-8 (ZIF-8) nanoparticles to treat bacteria-infected cutaneous wounds.
View Article and Find Full Text PDFHigh-altitude polycythemia (HAPC) is a common plateau chronic disease in which red blood cells are compensatory hyperproliferative due to high altitude hypoxic environment. HAPC severely affects the physical and mental health of populations on the plateau. However, the pathogenesis and treatment of HAPC has been rarely investigated.
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