Histone deacetylases inhibitor trichostatin A increases the expression of Dleu2/miR-15a/16-1 via HDAC3 in non-small cell lung cancer.

Histone deacetylases (HDACs) inhibitor is a promising new approach to the treatment of lung cancer therapy via inhibiting cell growth and inducing apoptosis. miR-15a and miR-16-1 are important tumor suppressors through modulating B cell lymphoma 2 (Bcl-2), Cyclin D1, D2, and others. However, whether HDACs inhibitor modulates the expression of miR-15a/16-1 in lung cancer is still unknown.

[Resonance scattering detection of trace Hg2+ using aptamer modified AuSe nanoalloy].

Under the condition of sodium citrate as stabilizer, the gold-selenium (AuSe) nano-alloy was prepared by sodium borohydride reduction procedure, and was modified by single-strand aptamer to obtain an aptamer nano-alloy probe (apta-AuSe) for Hg(II). In pH 6.8 Na2HPO4-NaH2PO4 buffer solution and in the presence of NaCl of 33 mmol L(-1), the Apta-AuSe probe is not aggregation.

A highly sensitive aptamer-nanogold catalytic resonance scattering spectral assay for melamine.

The aptamer (ssDNA) was used to label nanogold (NG) particle to fabricate an aptamer-nanogold (NGssDNA) probe for melamine. The probe was stabile in pH 6.6 Na(2)HPO(4)-NaH(2)PO(4) buffer solutions and in the presence of high concentration of electrolyte.

Resonance scattering detection of trace melamine using aptamer-modified nanosilver probe as catalyst without separation of its aggregations.

Nanosilver was modified by aptamer (ssDNA) to obtain a resonance scattering (RS) probe (AgssDNA) for melamine (MA). Based on the catalytic effect of the probe on the Fehling particle reaction, a nanocatalytic RS assay is proposed for the determination of 0.02-1.