Network Pharmacologic Analysis of Extract Inhibiting the Proliferation of Gastric Cancer Cells.

Globally, gastric cancer (GC) is one of the three most deadly cancers. () is a traditional Chinese medicine (TCM), and its extract can significantly inhibit the proliferation of gastric cancer cells. However, there are no unified conclusions on its potential active components and possible mechanisms of action.

The roles of kinetochore of micronucleus in mitosis of HeLa cells: a live cell imaging study.

Background: Micronuclei (MNi) are extensively used to evaluate genotoxic effects and chromosome instability. However, the roles of kinetochore of MN in mitosis have not been completely addressed.

Methods: The HeLa CENP B-GFP H2B-mCherry cells are applied to address these questions via the long-term live-cell imaging.

Recombinant human growth hormone (rhGH) treatment of MKN-45 xenograft mice improves nutrition status and strengthens immune function without promoting tumor growth.

The aim of this study was to clarify the combined effects and dose-effect relationships of rhGH on tumor growth, nutrition status, and immune function in MKN-45 xenograft mice. In this study, animal models were induced in nude mice using the subcutaneous transplantation of MKN-45 cells, and rhGH was injected daily for 14 days. Three rhGH treatment dosages were set with reference to the equivalent dosage converted from human clinical dosage, including 2 IU (0.

Extraction and Analysis of Gigantol from Dendrobium officinale with Response Surface Methodology.

In order to optimize the extraction of gigantol from , the influence of methanol concentration, ultrasonic temperature, and liquid ratio on extraction efficiency was analysed by the response surface analysis method. The results show that the extraction rate reached a maximum when the methanol concentration was 92.98%, the solid-liquid ratio was 27.