Publications by authors named "Lianne McCarthy"
Background: CHD is associated with considerable burden of care. Up to one-third of babies born with CHD require surgery or intervention during the first year of life with an associated increased risk of surgical site infection. Pediatric wound care is informed largely by adult data, with no national or international guidelines available.
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- Cardiac surgery using cardiopulmonary bypass (CPB) can lead to multiorgan dysfunction (CSA-MOD), which includes issues like acute kidney injury and myocardial damage, potentially caused by oxidative stress.
- This study assessed whether avoiding high levels of oxygen in the blood (arterial hyperoxemia) during CPB could lessen oxidative stress and reduce organ dysfunction.
- After analyzing 298 patients, the study found that avoiding hyperoxemia did not significantly affect the occurrence of kidney injury, other organ damage markers, or the length of hospital stays.
Background: In intensive care observational studies, hypercapnia after cardiac arrest (CA) is independently associated with improved neurological outcome. However, the safety and feasibility of delivering targeted therapeutic mild hypercapnia (TTMH) for such patients is untested.
Methods: In a phase II safety and feasibility multi-centre, randomised controlled trial, we allocated ICU patients after CA to 24h of targeted normocapnia (TN) (PaCO2 35-45mmHg) or TTMH (PaCO2 50-55mmHg).
Background: The optimal strategy for fluid replacement after major surgery remains unclear and there is considerable interest in the investigation of more restrictive fluid regimens.
Objective: We aimed to establish current practice of fluid administration to patients after cardiac surgery.
Design, Setting And Participants: A multicentre, prospective observational study, over an 8-week period, of consecutive patients admitted to five intensive care units in New Zealand and Australia.