Publications by authors named "Lianlian Zhang"

Article Synopsis
  • - This study aimed to investigate how immune cell traits and metabolites might causally relate to Guillain-Barre syndrome (GBS), using a Mendelian randomization approach with data from a genome-wide association study.
  • - Results revealed that higher levels of CD3 on activated and secreting regulatory T cells significantly increased the risk of GBS, while the plasma metabolite N-Acetyl-L-Alanine (ALA) also showed a positive correlation with GBS.
  • - The findings suggest that the influence of CD3 on GBS is partially mediated by ALA, providing insights that could guide future clinical research and interventions related to GBS.
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  • A study explored the link between cardiovascular risk factors and intraplaque neovascularization, which indicates plaque vulnerability in symptomatic patients using Contrast-Enhanced Ultrasound (CEUS).
  • Out of 157 evaluated patients, those with diabetes, dyslipidemia, hypertension, and smokers were more likely to show intraplaque neovascularization, with diabetes having the strongest association.
  • The findings highlight that patients with higher glucose levels and fewer statin treatments are significant indicators for increased intraplaque neovascularization, suggesting a complex relationship between glucose control and vascular health.
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This study aims to explore the value of nimodipine combined with Ginkgo biloba extract in improving cognitive function and daily living abilities in patients with Parkinson's disease. Clinical data from 551 patients with Parkinson's disease admitted to the Neurology Department of the Affiliated Hospital of Beihua University from January 2022 to December 2022 were retrospectively collected. Cognitive function and daily living abilities were assessed in patients before treatment, and a reevaluation was conducted after 12 weeks of medication.

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  • The DPC algorithm is effective for sample distribution and noise point identification but lacks adaptability and struggles with high time complexity.
  • This study introduces improvements to DPC using maximum nearest neighbor distance and K-nearest neighbors, and proposes a new method based on delayed spiking neural P systems (DSN P systems).
  • The new DSNP-ANDPC algorithm demonstrates superior performance in most cases when evaluated against various synthetic and real-world datasets.
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  • SCN4B, a sodium voltage-gated channel beta subunit, has a suppressive role in tumors, but its function in non-small cell lung cancer (NSCLC) is not fully understood.
  • The study utilized TCGA data and various analysis methods to investigate SCN4B expression and its relationship with prognosis in NSCLC patients.
  • Results show that SCN4B is significantly downregulated in NSCLC tissues compared to normal tissues and is correlated with poor clinical outcomes.
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We investigate the role of the black-phosphorus-based n-p (BP-np) junction modulated by linearly polarized light (LPL) in governing the quantum transport behaviors. Following the analysis of the band structures, we find that the LPL can adjust the gap between the conduction and valence bands by reducing the impact of momentum mismatch caused by the band gap. In addition, LPL can also eliminate the angle dependence of transmission.

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Purpose: This study explored the correlation between inflammatory markers and ulcerative plaques based on carotid doppler ultrasound (CDU) in individuals with acute ischemic stroke (AIS).

Methods: A total of 202 cases diagnosed with AIS associated with atherosclerotic plaque (AP) in the carotid artery were enrolled in this research. Collecting clinical baseline data, laboratory data (such as the complete blood count) and imaging data (CDU and Brain magnetic resonance imaging [MRI]).

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  • This study explores the use of borophene as a material for gas-sensing devices, focusing on its ability to detect minor pollutant gases through density functional theory (DFT).
  • The research compares the sensing performance of three types of borophenes (two Pmmn borophenes and χ-borophene) with five harmful gases (CO, NH, SO, HS, and NO), analyzing their adsorption mechanisms and energy.
  • Results show that χ-borophene demonstrates selective interactions with harmful gases via both physisorption and chemisorption, suggesting its potential for sensitive gas detection and removal applications.
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One of the critical techniques for developing hydrogen storage applications is the advanced research to build novel two-dimensional materials with significant capacity and effective reversibility. In this work, we perform first-principles unbiased structure search simulations to find a novel AsC5 monolayer with a variety of functionally advantageous characteristics. Based on theoretical simulations, the proposed AsC5 has been found to be energetically, dynamically, and thermally stable, supporting the viability of experiment.

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Objectives: This study aimed to determine whether texture analysis (TA) and machine learning-based classifications can be applied in differential diagnosis of cardiac amyloidosis (CA) and hypertrophic cardiomyopathy (HCM) using non-contrast cine cardiac magnetic resonance (CMR) images.

Methods: In this institutional review board-approved study, we consecutively enrolled 167 patients with CA ( = 85), HCM ( = 82), and 84 patients with normal CMR served as controls. All cases were randomized into training [119 patients (70%)] and validation [48 patients (30%)] groups.

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  • Vulnerable carotid plaques are linked to a higher risk of ischemic stroke, making it important to quickly identify their nature.
  • This study investigated the relationship between the systemic immune-inflammation index (SII)—an indicator derived from blood tests—and carotid plaque vulnerability in 131 patients with acute ischemic stroke.
  • Results showed that higher SII levels were associated with unstable plaques and increased risk of plaque rupture, demonstrating SII as an independent risk factor for plaque vulnerability and correlating with stroke severity.
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Background: Early mobilization in the intensive care unit (ICU) is a hotspot. This study aims to provide a bibliometric perspective of the progress in this field.

Methods: We extracted publications on ICU early mobilization published in the Web of Science Core Collection database from 2000 to 2021.

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Ischemic stroke (IS) exhibits a high disability rate, mortality, and recurrence rate, imposing a serious threat to human survival and health. Its occurrence is affected by various factors. Although the previous research has demonstrated that the occurrence of IS is mainly associated with lumen stenosis caused by carotid atherosclerotic plaque (AP), recent studies have revealed that many patients will still suffer from IS even with mild carotid artery lumen stenosis.

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Vulnerable carotid plaques are closely related to the occurrence of ischemic stroke. Therefore, accurate and rapid identification of the nature of carotid plaques is essential. This study aimed to determine whether texture analysis based on a vascular ultrasound can be applied to identify vulnerable plaques.

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Background: Globally, non-small-cell lung cancer (NSCLC) is one of the most prevalent tumors. Various studies have investigated its etiology, but the molecular mechanism of NSCLC has not been elucidated.

Methods: The GSE19804, GSE118370, GSE19188, GSE27262, and GSE33532 microarray datasets were obtained from the Gene Expression Omnibus (GEO) database for the identification of genes involved in NSCLC development as well as progression.

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We investigate the quantum transmission through the n-p-n heterojunction of massive 8-borophene. It is found that the Dirac mass of the electron interacts nontrivially with the anisotropy of the 8-borophene, leading to the occurrence of new transmission behaviors in this n-p-n heterojunction. Firstly, the effective energy range of nonzero transmission can be reduced but deviates from the mass amplitude, which induces the further controllability of the transmission property.

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Background: Investigating anti-oxidant therapies that lead to the diminution of oxidative injury is priority in clinical. We herein aimed to explore whether and how Licochalcone B (Lico B) act as an anti-oxidant in the stroke model.

Methods: Middle cerebral artery occlusion (MCAO) was constructed as stroke model and exposed to various doses of Lico B.

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We investigate the effect of quantum interference on the Andreev reflections (ARs) induced by Majorana bound states (MBSs), by considering their additional coupling via a quantum-dot molecule. It is found that due to the direct and indirect couplings of MBSs, a quantum ring is constructed in this system. Consequently, the interference effect makes important contribution to the ARs, especially in the presence of the local magnetic flux.

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We theoretically investigate the frustrated double ionization (FDI) of Ar atoms with counter-rotating two-color circular (CRTC) laser fields using the three-dimensional (3D) classical ensemble method. Our results show that the FDI probability depends upon the intensity ratio of the CRTC laser fields. The FDI event accompanied with the recollision excitation with subsequent ionization is prevalent and three pathways exist in FDI processes driven by CRTC laser fields.

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Hepatocellular carcinoma (HCC) is one of the common malignant tumors with poor overall prognosis. As a tumor suppressor, the function of miR-559 in HCC is not clear. In this study, quantitative real-time PCR was carried out to measure the expression of miR-559 in HCC cell lines.

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We theoretically study the transport properties in a one-dimensional photonic lattice influenced by the presence of side-coupled -symmetric non-Hermitian defects. The symmetry is manifested as the complex potentials on the defects and the complex defect-lattice couplings, respectively. These two mechanisms are found to induce the Fano effect in the transport processes, with the different characteristics of it.

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By introducing the next-nearest-neighboring (NNN) intersite coupling, we investigate the eigenenergies of the [Formula: see text]-symmetric non-Hermitian Su-Schrieffer-Heeger (SSH) model with two conjugated imaginary potentials at the end sites. It is found that with the strengthening of NNN coupling, the particle-hole symmetry is destroyed. As a result, the bonding band is first narrowed and then undergoes the top-bottom reversal followed by the its width's increase, whereas the antibonding band is widened monotonously.

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