Publications by authors named "Lianlian You"
Introduction: Patients undergoing hemodialysis (HD) are highly vulnerable during the COVID-19 pandemic. We aimed to investigate the risk factors associated with the severity of COVID-19 and death after the complete liberalization of epidemic control in China.
Methods: We followed the outcomes of the HD patients of Central Hospital of Dalian University of Technology, from December 6, 2022, to January 8, 2023.
Article Synopsis
- - The study examines the effects of roxadustat, a type of HIF-PHI, on inflammation and iron metabolism in patients with renal anemia who do not respond to traditional treatments like ESAs, focusing on gut microbiota changes over three months.
- - Results showed significant increases in hemoglobin levels and beneficial gut bacteria associated with short-chain fatty acids, while inflammation markers and iron-related proteins in the blood decreased, suggesting a positive impact on both anemia and inflammation.
- - Notably, specific gut bacteria, such as Alistipes shahii, were negatively correlated with inflammatory markers like IL-6 and TNF-α, indicating the potential role of gut health in managing anemia and inflammation.
Background: The association between serum β-microglobulin (βM) levels and the risk of all-cause and cardiovascular disease (CVD) mortality and the incidence of cardiovascular events (CVEs) in patients undergoing maintenance hemodialysis (MHD) is inconclusive. Furthermore, no study has been performed in China on the significance of serum βM levels in MHD patients. Therefore, this study investigated the aforementioned association in MHD patients.
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- Poor sleep quality affects many hemodialysis (HD) patients, and this study investigated how dietary fiber intake relates to sleep quality among Chinese HD patients.
- Researchers assessed the dietary habits and sleep quality of 741 patients using questionnaires and found that higher fiber intake is linked to better sleep quality.
- The results suggest that increasing dietary fiber consumption, particularly insoluble and vegetable-sourced soluble fiber, could help improve sleep quality in HD patients.
Background: Roxadustat is a newly marketed hypoxia-inducible factor prolyl hydroxylase inhibitor used to treat anemia in patients with end-stage renal disease (ESRD). While clinical trials have demonstrated the therapeutic effects of roxadustat in patients with ESRD who are resistant to erythropoiesis-stimulating agents (ESAs), its metabolic effects are still unclear.
Methods: Thirty-two individuals with ESRD and ESA resistance from the Blood Purification Center of Dalian Municipal Central Hospital were included.
Dialysis adequacy is a known risk factor for mortality in maintenance hemodialysis (MHD) patients. However, the optimal dialysis dose remains controversial. Therefore, we aimed to explore the relationship between dialysis dose and all-cause and cardiovascular disease (CVD) mortality among MHD.
View Article and Find Full Text PDFBackground: The association between serum total indoxyl sulfate (tIS), and cardiovascular disease (CVD) and all-cause mortality is a matter of debate. In the current study we sought to determine the association, if any, between serum tIS, and all-cause and CVD-associated mortality in patients on maintenance hemodialysis (MHD).
Methods: A prospective cohort study was conducted involving 500 MHD patients at Dalian Municipal Central Hospital from 31 December 2014 to 31 December 2020.