Publications by authors named "Lianjie Ye"
The Effect of Polyhydroxy Fullerene Derivative on Human Myeloid Leukemia K562 Cells.
Materials (Basel)
February 2022
Article Synopsis
- Nanomedicines, particularly hydroxylated fullerene C(OH)(n = 18-22), have notable effects on treating solid tumors and chronic myeloid leukemia.
- At low concentrations (less than 120 μM), this fullerene can enhance the growth of K562 leukemia cells while showing toxic side effects, while higher concentrations (over 160 μM) inhibit cell proliferation and induce significant cellular damage, including apoptosis and cell cycle arrest.
- The study suggests that the fullerene's effects on solid tumors may be influenced by the tumor microenvironment, with a noted safety profile at specific concentrations.
The development of novel nanoparticles as a new generation therapeutic drug platform is an active field of chemistry and cancer research. In recent years, fullerene nanoparticles have received extensive attention due to their unique physical and chemical properties. Properly modified fullerene nanoparticles have excellent biocompatibility and significant anti-tumor activity, which makes them have broad application prospects in the field of cancer therapy.
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