LXRα agonist differentially regulates BAFF expression and biological effects in RAW264.7 cells depending on growth status: LXRα activation and BAFF signaling in RAW264.7 cells.

B- cell-activating factor (BAFF), which is essential for the survival and development of B cells, is mainly produced by myeloid cells such as macrophages. Abnormal macrophage infiltration and high BAFF expression in kidney allografts are associated with the occurrence and development of antibody-mediated rejection (ABMR). Nuclear hormone receptor Liver X receptors (LXRs), is a nonnegligible participant in regulating cholesterol metabolism and inflammatory responses.

Dynamic Diselenide Hydrogels for Controlled Tumor Organoid Culture and Dendritic Cell Vaccination.

Dynamic hydrogels are emerging as advanced materials for engineering tissue-like environments that mimic cellular microenvironments. We introduce a diselenide-cross-linked hydrogel system with light-responsive properties, designed for precise control of tumor organoid growth and light-initiated radical inactivation, particularly for dendritic cell (DC) vaccines. Diselenide exchange enables stress relaxation and hydrogel remodeling, while recombination and quenching of seleno radicals (Se) reduce cross-linking density, leading to controlled degradation.

The double face of licorice-kansui herb pair: Cure or curse, depending on the combining ratio and mediated by hydrogen sulfide.

Background: The safety and efficacy of herbal medicines including traditional Chinese medicine (TCM) has been one of the major scientific problems in the medical field. In TCM prescriptions, reasonable herbal combinations bring stronger efficacy and low risk of toxicity. However, the rules and mechanisms for herbal combinations are far from complete understood yet.

Nonheme iron catalyst mimics heme-dependent haloperoxidase for efficient bromination and oxidation.

The [Fe]/HO oxidation system has found wide applications in chemistry and biology. Halogenation with this [Fe]/HO oxidation protocol and halide (X) in the biological system is well established with the identification of heme-iron-dependent haloperoxidases. However, mimicking such halogenation process is rarely explored for practical use in organic synthesis.

Correction: A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency.

Correction for 'A bottlebrush-architectured dextran polyprodrug as an acidity-responsive vector for enhanced chemotherapy efficiency' by Tian Zhang, , , 2020, , 473-484, https://doi.org/10.1039/C9BM01692A.

Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis.

Introduction: The incidence of chronic obstructive pulmonary disease (COPD) appears to be increasing and evidence suggests that the intestinal flora may play a causative role in its development. Previous studies found that the Shenqi Wenfei Formula (SQWF) can regulate pyroptosis via the NLRP3/GSDMD pathway, thereby reducing the inflammatory response in the lungs of COPD model rats. However, there is no information on whether the drug's effects are associated with intestinal flora.

An upgraded chassis with enhanced growth characteristics for efficient genetic manipulation.

Myxobacteria are well known for multicellular social behaviors and valued for biosynthesis of natural products. Myxobacteria social behaviors such as clumping growth severely hamper strain cultivation and genetic manipulation. Using DK1622, we engineered Hu04, which is deficient in multicellular behavior and pigmentation.

Efficacy and safety of once-weekly insulin versus once-daily insulin in patients with type 1 and type 2 diabetes mellitus: an updated meta-analysis of randomized controlled trials.

Background: This meta-analysis was performed to obtain a comprehensive overview of the differences between once-weekly basal insulin (including icodec and basal insulin Fc) and once-daily basal insulin (including glargine and degludec) in patients with type 1 and type 2 diabetes mellitus.

Methods: PubMed, EMBASE, and Cochrane Library were systematically searched for eligible studies up to 2 January 2024.

Results: A total of 12 studies were included, comprising 5,895 patients, with 3,104 (52.

[Atmospheric HONO Concentration Levels and Generation Mechanisms in Nanjing in Winter and Summer].

HONO, or gaseous nitrous acid, has a significant impact on air quality and climate. An atmospheric gaseous nitrous acid （HONO） observation study was carried out in December 2021 （winter） and July 2022 （summer） in the Jiangbei New District of Nanjing City, respectively. Using the HONO concentration observation data, combined with the atmospheric NO and O concentrations during the sampling period as well as the reaction rate of the HONO generation process and other parameters, we compared and analyzed the change rule of the atmospheric HONO concentration during winter and summer in the Nanjing area, quantitatively investigated the sources of diurnal atmospheric HONO and its generation mechanism, and explored the unknown sources of atmospheric HONO during the daytime.

[Characteristics and Sources of Volatile Organic Compounds （VOCs） in Luohe City During Summer].

Luohe City is an important node city in the Central Plains Urban Agglomeration in China, where the atmospheric ozone （O） pollution situation has been serious in recent years. In order to provide a scientific basis for O pollution control, the online filed observation of O precursor volatile organic compounds （VOCs） was carried out in Luohe City in July 2022 to understand their variation characteristics and sources. The mean ratio of （TVOCs） during the observation period was （16.

Function of PxGrp78 in the Reproduction of Plutella xylostella.

Glucose-regulated protein 78 (Grp78), a crucial molecular chaperone in the endoplasmic reticulum, has been extensively investigated in vertebrates. However, its functional exploration in insects remains limited. This study cloned the full-length cDNA sequence of Grp78 in Plutella xylostella (L.

Effects of Virtual Reality on Relieving Pain During Endoscopy in Adults: A Systematic Review and Meta-Analysis of Randomised Clinical Trials.

Background: Virtual reality is an emerging non-drug treatment for pain caused by endoscopy procedure. We conducted a meta-analysis to evaluate the effectiveness and safety of virtual reality based interventions for pain during endoscopy.

Methods: PubMed, EMBASE, Cochrane Library, Web of Science and Clinical Trials database were searched until 26 May 2024.

Improving primary healthcare quality in China through training needs analysis.

The diagnosis and treatment capability levels of healthcare professionals directly affect the overall quality of medical services. Enhancing these capability levels requires strengthening the professional skill training of healthcare workers, especially those in primary care settings in economically underdeveloped areas. To understand the actual needs for professional skill training among primary healthcare workers, thereby providing data support for targeted training initiatives.