Degradation of AFB in edible oil by aptamer-modified TiO composite photocatalytic materials: Selective efficiency, degradation mechanism and toxicity.

Most of the excessive aflatoxins in peanut oil are present at lower levels, and few photocatalysts have been reported for degrading low concentrations of aflatoxin B (AFB). This study employed aptamer-modified magnetic graphene oxide/titanium dioxide (MGO/TiO-aptamer) photocatalysts to degrade low concentrations of AFB in peanut oil, thoroughly investigating their selective efficiency, degradation mechanism, and product toxicity. The results indicated that the modification of aptamers on the surface of photocatalytic materials can enhance the selectivity of photocatalysts for AFB in peanut oil.

Selective aptasensor of deoxynivalenol based on dual signal enhancement of thionine electrochemistry using silver nanoparticle-loaded label at gold nanoparticle-loaded electrodes.

In this work, an efficient sensing platform deoxynivalenol (DON) detection was constructed through monitoring the current change of a competitive mechanism triggered by DON, leading the signal label detached from the electrode surface by square-wave voltammetry using thionine (Thi) as a redox indicator. The complementary strand of aptamer (cDNA) and Thi were loaded onto Fe/Ni bimetallic metal-organic framework loaded with sliver nanoparticles (AgNPs@FeNi-MOF) to construct AgNPs@FeNi-MOF/cDNA/Thi signal probes. In the presence of DON, the aptamer sequence was more predisposed to form an aptamer-DON complex, resulting in the displacement of the cDNA.

Risk of incident type 2 diabetes in male NAFLD and NAFLD-free smokers: a 7-year post-cessation study.

Background: We aimed to investigate the post-cessation T2DM risk in male NAFLD and NAFLD-free smokers in a 7-year cohort study.

Methods: The study population was male adults who underwent annual health checkups in a 7-year cohort study. Recent quitters were categorized into four groups based on their weight gain during follow-up: < 0 kg, 0-1.

The reliability and validity of Child-to-parent Violence Questionnaire (CPV-Q) among Chinese adolescents.

Objective: To test the reliability and validity of the Chinese version of the Child-to-parent Violence Questionnaire (CPV-Q) in a group of Chinese adolescents.

Methods: A total of 1138 adolescents (15.24 ± 1.

Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice.

Introduction: Alzheimer's Disease (AD), a progressive neurodegenerative disorder, is marked by cognitive deterioration and heightened neuroinflammation. The influence of Insulin-like Growth Factor 1 Receptor (IGF1R) and its post-translational modifications, especially sumoylation, is crucial in understanding the progression of AD and exploring novel therapeutic avenues.

Objectives: This study investigates the impact of exercise on the sumoylation of IGF1R and its role in ameliorating AD symptoms in APP/PS1 mice, with a specific focus on neuroinflammation and innovative therapeutic strategies.

Estimated small dense low-density lipoprotein cholesterol and nonalcoholic fatty liver disease in nonobese populations.

Aims/introduction: To explore the association between estimated small dense low-density lipoprotein cholesterol (sdLDL-C) and the risk of incident nonalcoholic fatty liver disease (NAFLD) in nonobese populations.

Materials And Methods: This study included participants who underwent health checkups in 2014 and were followed up until 2019. We carried out Cox proportional hazards regression analyses to evaluate the association of estimated sdLDL-C with NAFLD.

A dual-cycle amplification-based electrochemical platform for sensitive detection of tobramycin.

Background: Tobramycin (TOB), an essential aminoglycoside antibiotic in human life, poses potential threats due to its residues in the environment. The primary concern is the adverse impact of excessive TOB on human kidneys, hearing, and other organs, significantly affecting human health. Constructing a sensitive electrochemical platform for simple and rapid trace detection is crucial.

Guideline on treating community-acquired pneumonia with Chinese patent medicines.

Community-acquired pneumonia (CAP) is one of the most common infectious diseases, and its morbidity and mortality increase with age. Resistance and mutations development make the use of anti-infective therapy challenging. Chinese patent medicines (CPMs) are often used to treat CAP in China and well tolerable.

HLA-DQA1 expression is associated with prognosis and predictable with radiomics in breast cancer.

Background: High HLA-DQA1 expression is associated with a better prognosis in many cancers. However, the association between HLA-DQA1 expression and prognosis of breast cancer and the noninvasive assessment of HLA-DQA1 expression are still unclear. This study aimed to reveal the association and investigate the potential of radiomics to predict HLA-DQA1 expression in breast cancer.

The effects of ethical leadership on creativity: A conservation of resources perspective.

The pursuit of novelty can be a challenging experience that often comes with stress. Thinking outside the box can even lead to ethical dilemmas, particularly when innovators are under the pressure to meet deadlines. In this study, we examine creativity as a stress-inducing process, especially when employees encounter setbacks during their pursuit of novelty.

Effect of Nasal Irrigation in Children With Omicron Variant of COVID-19 Infection.

To explore the effect of nasal irrigation on the disappearance of symptoms and nucleic acid conversion in children with Omicron variant. This quasi-experimental study included children diagnosed with asymptomatic, mild, and moderate Omicron variant infection during the isolation observation period in the Shandong Public Health Clinical Center between April 1, 2022 and May 1, 2022. The children were divided into a routine group (received Lianhua Qingwen (LhQw) Granules), isotonic saline group (received LhQw Granules combined with isotonic saline nasal irrigation), and hypertonic saline group (received LhQw Granules combined with 3% hypertonic saline nasal irrigation), respectively.

Remnant Cholesterol Independently Predicts the Development of Nonalcoholic Fatty Liver Disease.

Context: Serum levels of remnant cholesterol have been reported to predict the prognosis of cardiovascular disease, independent of traditional lipid profiles.

Objective: This study aimed to explore the association between serum remnant cholesterol and the development of nonalcoholic fatty liver disease (NAFLD).

Methods: A total of 9184 adults who underwent physical examination annually were included in this study.

Porous Graphitic phase carbon nitride/graphene oxide hydrogel microspheres for efficient and recyclable degradation of aflatoxin B in peanut oil.

Removal of aflatoxin is an urgent issue in agricultural products. A porous graphitic carbon nitride/graphene oxide hydrogel microsphere (CN/GO/SA) was synthesized and used to degrade AFB in peanut oil. CN/GO/SA was characterized by scanning electron micrograph (SEM), X-ray diffraction (XRD) and FT-IR.

The efficacy of traditional Chinese medicine in the treatment of the COVID-19 pandemic in Henan Province: a retrospective study.

Background: Since 2020, novel coronavirus disease (COVID-19) has posed serious threats to health systems and led to tremendous economic decline worldwide. Traditional Chinese medicine (TCM) is considered a promising treatment strategy for COVID-19 in China and is increasingly recognized as a key participant in the battle against COVID-19. Clinicians also need accurate evidence regarding the effectiveness of TCM treatments for COVID-19.

Effect of nasal irrigation in adults infected with Omicron variant of COVID-19: A quasi-experimental study.

Objective: To investigate the effect of nasal irrigation on the duration of symptoms and nucleic acid conversion in adults infected with the Omicron variant of COVID-19.

Methods: This quasi-experimental study enrolled patients diagnosed with asymptomatic, mild, or moderate Omicron infection at the Shandong Public Health Clinical Center between April 1, 2022 and May 1, 2022. Patients were divided into two groups to receive Lianhua Qingwen granules and traditional Chinese medicine (TCM) prescriptions (conventional group) and 3% hypertonic saline nasal irrigation based on conventional treatment (nasal irrigation groups), respectively.

[Management of immunocompromised renal transplant patients infected with coronavirus disease 2019].

Objective: To analyze the treatment process of a renal transplant patient infected with coronavirus disease 2019 (COVID-19), and discuss the management strategy for the immunocompromised hosts.

Methods: The diagnosis and treatment of a case of transplant patients with COVID-19 admitted to Horgos designated hospital of Xinjiang Uygur Autonomous Region in October 2021 were reviewed. The medical history and laboratory and imaging examination treatment and outcome of this case were analyzed.

Influence of traditional Chinese medicines on the metabolism of lopinavir/ritonavir based on UHPLC-MS/MS analysis.

A fast, reliable, and cost-effective liquid chromatography-tandem mass spectrometry method was established to determine the effects of the traditional Chinese medicine employed to treat coronavirus disease 2019, namely, Lianhua Qingwen granules, Huoxiang Zhengqi capsules, Jinhua Qinggan granules, Shufeng Jiedu capsules, and Angong Niuhuang pills, on the pharmacokinetics of lopinavir/ritonavir in rats. Blood samples were prepared using the protein precipitation method and atazanavir was selected as the internal standard (IS). Separation was performed on an Agilent ZORBAX eclipse plus C (2.

Acute glycemic variability and mortality of patients with acute stroke: a meta-analysis.

Background: Increased glucose fluctuation has been related to poor prognosis in patients with critical illnesses, while its prognostic role in patients with acute stroke remains unknown. The meta-analysis aimed to evaluate the association between the acute glycemic variation (GV) and mortality risk in patients with acute stroke.

Methods: Cohort studies were obtained by searching Medline, Web of Science, Embase, Wanfang and CNKI databases.

Au@ZnNi-MOF labeled electrochemical aptasensor for detection of enrofloxacin based on AuPt@h-CeO/MoS and DNAzyme-driven DNA walker triple amplification signal strategy.

Herein, an aptasensor based on Pb dependent DNAzyme driven DNA Walker with the triple amplification signal strategy was developed for ultrasensitive detection of enrofloxacin (ENR). The composite of Au & Pt coated hollow cerium oxide (AuPt@h-CeO), and polyethyleneimine (PEI) functionalized molybdenum disulfide (PEI-MoS) were used as the substrate material to increase the specific surface area of the electrode and attach more DNA probes. In the presence of ENR, the aptamer can break away from the double-stranded structure, releasing DNAzyme capable of cleaving circular RNA with the help of Pb, which in turn will generate a large number of capture probes that bind the signal probes.

Intratumoral and peritumoral radiomics for preoperative prediction of neoadjuvant chemotherapy effect in breast cancer based on contrast-enhanced spectral mammography.

Objective: To investigative the performance of intratumoral and peritumoral radiomics based on contrast-enhanced spectral mammography (CESM) to preoperatively predict the effect of the neoadjuvant chemotherapy (NAC) of breast cancers.

Materials And Methods: A total of 118 patients with breast cancer who underwent preoperative CESM and NAC from July 2017 to June 2020 were retrospectively analyzed, and the patients were grouped into training (n = 81) and test sets (n = 37) according to the CESM examination time. NAC effect for each patient was assessed by pathology.

Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019.

Background: Coronavirus disease 2019 (COVID-19) has become a worldwide life-threatening pandemic. Lianhua Qingwen is believed to possess the ability to treat or significantly improve the symptoms of COVID-19. These claims make it important to systematically evaluate the effects of using Lianhua Qingwen with Western medicine to treat COVID-19.

Ultrasensitive detection of PCB77 based on Exonuclease III-powered DNA walking machine.

In view of the urgent need to determine polychlorinated biphenyls (PCBs) in the environment, we report a simple and sensitive electrochemical aptasensor to detect 3,3',4,4'-tetrachlorobiphenyl (PCB77) based on Exonuclease III-powered Deoxyribonucleic Acid (DNA) walking machine using poly (diallyldimethylammonium chloride) (PDDA), which was functionalized hollow porous graphitic carbon nitride/ Ni-Co hollow nanoboxes/ Au-Pd-Pt nanoflowers composite material. Upon the addition of PCB77, the specific binding between PCB77 and the aptamer (Apt) could trigger the Exo III-assisted cyclic amplification process and release unlocking probes to deblock the Swing arm/Blocker duplex. Finally, the hybridized hairpin 3 (HP3), a short oligonucleotide, was left on the electrode via Exo III digestion of hybridized HP2, and thus a strong methylene blue (MB) signal was obtained.

The Treatment Effect of Protamine on Severe Coagulopathy in Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis: Case Reports and Literature Review.

Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening disease, which is characterized by severe systemic inflammation with cytokine storm as well as histologic evidence of hemophagocytosis. Besides, coagulopathy and hemorrhages are two common severe complications in HLH patients. Recent literatures indicate that Epstein-Barr virus (EBV) infection is one of the important triggers for the disease.

An enhanced enzyme-linked aptamer assay for the detection of zearalenone based on gold nanoparticles.

A novel enhanced enzyme-linked aptamer assay (ELAA) for the detection of zearalenone (ZEN) was developed based on gold nanoparticles (AuNPs) modified with an aptamer and horseradish peroxidase (HRP). In this assay, the aptamer was used as a recognition probe to competitively bind with coated ZEN-BSA on a microplate and ZEN in samples. AuNPs with high surface areas were used as a carrier to immobilize more amounts of HRP labelled aptamer probe, which can amplify the colorimetric signal by enhancing catalysis of the HRP enzyme compared with the traditional enzyme-linked method.