Typical and extreme weather datasets for studying the resilience of buildings to climate change and heatwaves.

We present unprecedented datasets of current and future projected weather files for building simulations in 15 major cities distributed across 10 climate zones worldwide. The datasets include ambient air temperature, relative humidity, atmospheric pressure, direct and diffuse solar irradiance, and wind speed at hourly resolution, which are essential climate elements needed to undertake building simulations. The datasets contain typical and extreme weather years in the EnergyPlus weather file (EPW) format and multiyear projections in comma-separated value (CSV) format for three periods: historical (2001-2020), future mid-term (2041-2060), and future long-term (2081-2100).

Development and performance assessment of a new opensource Bayesian inference R platform for building energy model calibration.

Many factors contribute to the inherent uncertainty of energy consumption modeling in buildings. It is essential to perform a calibration and sensitivity analysis in order to manage these uncertainties. Despite the availability of several calibration methods, they are often deterministic and lack quantified uncertainties.

Evolution of the local climate in Montreal and Ottawa before, during and after a heatwave and the effects on urban heat islands.

The heatwave event to which the Ontario-Quebec area was subjected in 2018 resulted in significant morbidity and mortality. In this study, an investigation was conducted on how this heatwave affected the respective urban heat islands (UHIs) in Montreal and Ottawa. The modelled urban climates were compared before, during and after the heatwave using a Weather Research and Forecast (WRF) model having a 1 km spatial resolution.

Outdoor heat stress assessment using an integrated multi-scale numerical weather prediction system: A case study of a heatwave in Montreal.

More frequent and severe extreme weather events such as heatwaves are among the most serious challenges to society in coping with the changing climate. To evaluate the impacts of the heatwave on large-scale urban areas, a multi-scale weather forecasting system is designed by integrating different resolutions of the Canadian urbanized version of the Global Environmental Multiscale (GEM) Numerical Weather Prediction (NWP) model, cascading from 10 km to 2.5 km, and 250 m.

Development of a Bayesian inference model for assessing ventilation condition based on CO meters in primary schools.

Outdoor fresh air ventilation plays a significant role in reducing airborne transmission of diseases in indoor spaces. School classrooms are considerably challenged during the COVID-19 pandemic because of the increasing need for in-person education, untimely and incompleted vaccinations, high occupancy density, and uncertain ventilation conditions. Many schools started to use CO meters to indicate air quality, but how to interpret the data remains unclear.

Evaluating SARS-CoV-2 airborne quanta transmission and exposure risk in a mechanically ventilated multizone office building.

The world has faced tremendous challenges during the COVID-19 pandemic since 2020, and effective clean air strategies that mitigate infectious risks indoors have become more essential. In this study, a novel approach based on the Wells-Riley model applied to a multizone building was proposed to simulate exposure to infectious doses in terms of "". This modeling approach quantifies the relative benefits of different risk mitigation strategies so that their effectiveness could be compared.

Predictive value of the THRIVE score for outcome in patients with acute basilar artery occlusion treated with thrombectomy.

Background And Purpose: A higher Totaled Health Risks in Vascular Events (THRIVE) score has been shown to predict poor functional outcome in patients with acute ischemic stroke (AIS) and anterior circulation large vessel occlusions undergoing thrombectomy treatment. We attempted to evaluate the value of the THRIVE score in predicting the outcome of thrombectomy treatment in AIS patients with basilar artery occlusion (BAO).

Methods: A total of 68 AIS patients with BAO who underwent thrombectomy treatment from May 2014 to August 2018 were included in the present study.

Effects of pool size and spacing on burning rate and flame height of two square heptane pool fires.

The interaction of multiple pool fires might lead to higher burning rate and flame height than single pool fire, raising the possibility of fire ignition and flame spread and increasing the risks to people, buildings and environment. To quantify the burning rate and flame height of multiple pool fires from the view of physical mechanism, this paper presents an experimental study on two identical square pool fires. Heptane was used as fuel.

Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.

Functional disruption of the neurovascular unit may lead to aggravation of ischemic cerebral injury. Connexin43 (Cx43)-dependent gap junctional channels (GJCs) are critical in maintaining brain homeostasis. However, excessive opening of hemichannels (HCs) after cerebral ischemia may cause apoptosis and finally lead to amplification of ischemic injury.

Indoor thermal stratification and its statistical distribution.

Thermal stratification is established when warmer air rises and cooler air descends under thermal buoyancy. It occurs in indoor environment situations including large warehouse-type buildings, buoyancy-driven ventilated spaces with displacement, underfloor ventilation, and/or natural ventilation, and enclosure fires with hot smoke layer on top of cold air layer. This paper reports a recent study that thermal stratification of indoor environment follows the statistical Beta distribution so the vertical temperature distribution is the Cumulative Distribution Function of the Beta distribution defined by two shape parameters, Alpha (α) and Beta (β), despite ventilation types, heat source and other details.

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway.

Connexin 43 (Cx43) widely exists in all components of the neurovascular unit (NVU) and is a constituent of gap junctions and hemichannels. In physiological states, gap junctions are open for regular intercellular communication, and the hemichannels present low open probability in astrocytes. After cerebral ischemia, a large number of hemichannels are unusually opened, leading to cell swelling and even death.

In situ experimental study of carbon monoxide generation by gasoline-powered electric generator in an enclosed space.

On the basis of currently available data, approximately 97% of generator-related carbon monoxide (CO) fatalities are caused by operating currently marketed, carbureted spark-ignited gasoline-powered generators (not equipped with emission controls) in enclosed spaces. To better understand and to reduce the occurrence of these fatalities, research is needed to quantify CO generation rates, develop and test CO emission control devices, and evaluate CO transport and exposure when operating a generator in an enclosed space. As a first step in these efforts, this paper presents measured CO generation rates from a generator without any emission control devices operating in an enclosed space under real weather conditions.