Synopsis of recent research by authors named "Liangzhan Sun"
- Liangzhan Sun's recent research primarily focuses on understanding the molecular mechanisms underlying hepatocellular carcinoma (HCC) and its associated conditions, including tumor progression, metastasis, and resistance to treatment, particularly through epigenetic regulation and alternative splicing.
- Key findings reveal that histone methyltransferase ASH1L plays a significant role in promoting fibrosis-associated HCC by affecting tumor-associated macrophages, and USP39 is implicated in altering alternative splicing to drive hepatocellular carcinogenesis.
- Additionally, the research highlights the impact of cancer stem cells (CSCs) on tumor biology, suggesting that epigenetic reprogramming, including the inhibition of UHRF1 and the role of MAEL, could suppress tumor phenotypes and influence resistance to sorafenib in HCC.
