A Fast, Convenient, Polarizable Electrostatic Model for Molecular Dynamics.

We present an efficient polarizable electrostatic model, utilizing typed, atom-centered polarizabilities and the fast direct approximation, designed for efficient use in molecular dynamics (MD) simulations. The model provides two convenient approaches for assigning partial charges in the context of atomic polarizabilities. One is a generalization of RESP, called RESP-dPol, and the other, AM1-BCC-dPol, is an adaptation of the widely used AM1-BCC method.

Artificial potential function based spacecraft proximity maneuver 6-DOF control under multiple pyramid-type constraints.

This paper addresses the problem of spacecraft six degree of freedom (6-DOF) pose tracking control with collision avoidance and field of view (FOV) pyramid-type constraints during the autonomous proximity maneuver. The constraints are modeled as pyramid envelopes, which can better represent some real cases with less conservativeness comparing with commonly used cone-shaped model. A novel modeling method is proposed to describe the pyramid-type constraints in the dual-quaternion frame.

Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach.

Hsp90 is a new promising target for cancer treatment. Many inhibitors have been discovered as therapeutic agents, and some have passed Phase I and II. However, no one is approved by FDA yet.

Human adipose liquid extract induces angiogenesis and adipogenesis: a novel cell-free therapeutic agent.

Background: Taking advantage of cellular paracrine mechanisms, the secretome of adipose-derived stem cells (ADSCs) and adipose tissue has been demonstrated to induce tissue repair and regeneration in various ischemic and impaired conditions. However, these cell-based therapies have been hindered by issues, such as inherent safety and cost-efficiency for clinical applications. In this study, we prepared a liquid cell-free extract from human adipose tissue [adipose liquid extract (ALE)] and evaluated its potential therapeutic efficacy.

Reactive oxygen species altering the metabolite profile of the marine-derived fungus F31-1.

To investigate the influence of reactive oxygen species (ROS) on the secondary metabolites of the marine-derived fungus F31-1, hydrogen peroxide (HO) was added to the GPY culture medium. The HPLC chromatogram of the EtOAc extract of the culture broth was distinct from that of the HO free GPY medium. Further study of the metabolites in the GPY medium with HO resulted in the discovery of eight known compounds.

Treatment of human chronic wounds with autologous extracellular matrix/stromal vascular fraction gel: A STROBE-compliant study.

Stem cell therapy is considered as the most promising treatment for chronic wounds. Extracellular matrix/stromal vascular fraction gel (ECM/SVF gel), an adipose-derived stem cell-based cytotherapy, has shown healing potential in experimental wounds in animal models. However, the effects of ECM/SVF gel on human chronic wounds have not been investigated.