Publications by authors named "Liangying Zou"
Background: This study aims to investigate the altered spontaneous neural activity in patients with Parkinson's disease (PD) revealed by amplitudes of low-frequency fluctuations (ALFF) of resting-state fMRI, and the feasibility of using ALFF as neuroimaging predictors for motor improvement after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS).
Methods: Fourty-four patients and 44 healthy controls were included in this study. First, the ALFF of patients with PD was compared with that of controls; then significant clusters were correlated with motor improvement after DBS (unified Parkinson's disease rating scale (UPDRS-III)) and other clinical variables.
Background: Subthalamic nucleus (STN) deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD), that can improve patients' motor and non-motor symptoms. However, there are differences in the improvement of patients' emotional symptoms and cognitive function.
Objective: To investigate the impact of active contact location and the volume of tissue activated (VTA) on patients' emotional symptoms and cognitive function in STN-DBS in PD.
The amplitude of low-frequency fluctuation predicts levodopa treatment response in patients with Parkinson's disease.
Parkinsonism Relat Disord
November 2021
Introduction: Levodopa has become the main therapy for motor symptoms of Parkinson's disease (PD). This study aimed to test whether the amplitude of low-frequency fluctuation (ALFF) computed by fMRI could predict individual patient's response to levodopa treatment.
Methods: We included 40 patients.
Article Synopsis
- The study looked at how a treatment called STN-DBS affects balance in people with Parkinson's disease.
- They checked balance changes in 261 patients after the surgery and followed up with 111 patients later to see if they improved.
- The results showed that STN-DBS helped improve balance without medication but didn't work as well when patients were on their meds; also, how well a patient responded to another medicine called levodopa before surgery was important to predict their balance improvement after STN-DBS.