Gastric Cancer Models Developed via GelMA 3D Bioprinting Accurately Mimic Cancer Hallmarks, Tumor Microenvironment Features, and Drug Responses.

Current in vitro models for gastric cancer research, such as 2D cell cultures and organoid systems, often fail to replicate the complex extracellular matrix (ECM) found in vivo. For the first time, this study utilizes a gelatin methacryloyl (GelMA) hydrogel, a biomimetic ECM-like material, in 3D bioprinting to construct a physiologically relevant gastric cancer model. GelMA's tunable mechanical properties allow for the precise manipulation of cellular behavior within physiological ranges.

Prediction of Potential Risk for Ten Azole and Benzimidazole Fungicides with the Aryl Hydrocarbon Receptor Agonistic Activity to Aquatic Ecosystems.

Azole and benzimidazole fungicides are widely used agrochemicals to prevent and treat fungal growth and are frequently detected in aquatic environments. Here, we aimed to assess the aquatic ecological risks of ten currently used azole and benzimidazole fungicides, which with the aryl hydrocarbon receptor (AhR) agonistic activity, and their transformation products (TPs). We obtained over 400 types of aerobic TPs for ten fungicides.

Isolated Tin Enhanced CO Coverage-Regulation on SnCu Alloy for Selective CO Electroreduction to C Products.

Electricity-powered C─C coupling of CO represents an attractive strategy for producing valuable commodity chemicals with renewable energy, but it is still challenging to gain high C selectivity at high current density. Here, a SnCu single-atom alloy (SAA) is reported with isolated Sn atom embedded into the Cu lattice, as efficient ectrocatalyst for CO reduction. The as prepared SnCu-SAA catalyst shows a maximal C Faradaic efficiency of 79.

CD137 agonism enhances anti-PD1 induced activation of expanded CD8 T cell clones in a neoadjuvant pancreatic cancer clinical trial.

Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations. We provide a reference single-cell dataset from tumor-infiltrating leukocytes (TILs) from a human neoadjuvant clinical trial comparing the granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting allogeneic PDAC vaccine GVAX alone, in combination with anti-PD1 or with both anti-PD1 and CD137 agonist.

Semi-rational design of an aromatic dioxygenase by substrate tunnel redirection.

Lignin valorization is crucial for achieving economic and sustainable biorefinery processes. However, the enzyme substrate preferences involved in lignin degradation remain poorly understood, and low activity toward specific substrates presents a significant challenge to the efficient utilization of lignin. In this study, we investigated the substrate promiscuity of Ado, a key enzyme involved in lignin valorization.

Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis.

The term "gut microbiota" primarily refers to the ecological community of various microorganisms in the gut, which constitutes the largest microbial community in the human body. Although adequate bowel preparation can improve the results of colonoscopy, it may interfere with the gut microbiota. Bowel preparation for colonoscopy can lead to transient changes in the gut microbiota, potentially affecting an individual's health, especially in vulnerable populations, such as patients with inflammatory bowel disease.

Acupuncture Dosage and Its Correlation with Effectiveness in Patients with Chronic Stable Angina: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.

Objective: This systematic review aimed to compare the efficacy of various acupuncture dosages for Chronic Stable Angina (CSA) using randomized controlled trials (RCTs), addressing the unclear relationship between dosage and effectiveness despite acupuncture's potential.

Methods: We searched eight bibliographic databases from inception to October 31, 2024, evaluating RCTs comparing acupuncture to placebo or standard care for CSA patients, focusing on angina attack frequency as the primary outcome. Studies were categorized into high (HDG), moderate (MDG), and low (LDG) dosage groups based on acupuncture characteristics: the number of acupoints, total sessions, frequency per week, and the need for "Deqi".

Construction of geriatric hypoalbuminemia predicting model for hypoalbuminemia patients with and without pneumonia and explainability analysis.

Background And Objectives: Pneumonia portrays a critical health concern in geriatrics. Geriatric pneumonia can lead to changes on other complications, in which hypoalbuminemia is a common complication. However, few studies have looked at the impact of pneumonia on the course of hypoalbuminemia and predicting.

FTO Alleviates Hepatic Ischemia-Reperfusion Injury by Regulating Apoptosis and Autophagy.

Despite N-methyladenosine (mA) being closely involved in various pathophysiological processes, its potential role in liver injury is largely unknown. We designed the current research to study the potential role of fat mass and obesity-associated protein (FTO), an mA demethylase, on hepatic ischemia-reperfusion injury (IRI). Wild-type mice injected with an adeno-associated virus carrying fat mass and obesity-associated protein (AAV-FTO) or adeno-associated virus carrying green fluorescent protein (GFP) (AAV-GFP) were subjected to a hepatic IRI model in vivo.

Comparing heart PET scans: an adjustment of Kolmogorov-Smirnov test under spatial autocorrelation.

The principle of independence is a fundamental yet often disregarded assumption in statistical inference. It is observed that the implications of correlations, if not considered, can lead to a conservative estimation of Type I error in the presence of positive linear correlations when utilizing the Kolmogorov-Smirnov (KS) test. Conversely, negative linear correlations may engender a liberal estimation of Type I error.

Transarterial Chemoembolization Plus Radiofrequency Ablation and Iodine-125 Seed Implantation for Hepatocellular Carcinoma in High-Risk Locations: A Propensity Score-Matched Analysis.

Background & Aims: The effect of transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) (TACE-RFA) for hepatocellular carcinoma (HCC) in high-risk locations is not satisfactory. The aim of this study was to compare the clinical outcomes of TACE-RFA plus iodine-125 (I) seed implantation (TACE-RFA-I) therapy with those of TACE-RFA for unresectable HCC (≤5 cm) in high-risk locations.

Methods: From January 2010 to June 2023, the clinical data of 126 patients with unresectable HCC (≤5 cm) in high-risk locations who received TACE-RFA-I or TACE-RFA treatment were retrospectively analyzed.

Adipose tissue may not be a major player in the inflammatory pathogenesis of Autism Spectrum Disorder.

Purpose: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder increasingly recognized for its strong association with chronic inflammation. Adipose tissue functions as an endocrine organ and can secrete inflammatory cytokines to mediate inflammation. However, its involvement in ASD-related inflammation remains unclear.

The Relationship Between Insufficient Sleep and Depressive Symptoms in Chinese Adolescents: A National Survey of Contributing Factors.

Purpose: There is a lack of national studies examining the relationship between insufficient sleep and depression among Chinese adolescents, and previous research has not comprehensively considered related factors. This study aimed to investigate the prevalence of depressive symptoms in adolescents with insufficient sleep and explore the role of associated factors using a nationally representative sample in China.

Patients And Methods: A pen-and-paper survey was conducted among 24147 Chinese adolescents from November 2019 to January 2020.

Dapagliflozin combined with metformin improves blood glucose, bone metabolism and bone mineral density in elderly patients with type 2 diabetes mellitus complicated with osteoporosis.

The incidence of type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP) (T2DM-OP) is growing. Dapagliflozin and metformin are commonly prescribed to manage glycemic levels in T2DM patients. We investigated the clinical efficacy of combining dapagliflozin with metformin in elderly patients with T2DM-OP.

A Graph Neural Network-Based Approach to XANES Data Analysis.

The determination of three-dimensional structures (3D structures) is crucial for understanding the correlation between the structural attributes of materials and their functional performance. X-ray absorption near edge structure (XANES) is an indispensable tool to characterize the atomic-scale local 3D structure of the system. Here, we present an approach to simulate XANES based on a customized 3D graph neural network (3DGNN) model, XAS3Dabs, which takes directly the 3D structure of the system as input, and the inherent relation between the fine structure of spectrum and local geometry is considered during the model construction.

Gut microbiota and endometrial cancer: research progress on the pathogenesis and application.

As one of the three major malignant tumors in women, the morbidity of endometrial cancer is second only to that of cervical cancer and is increasing yearly. Its etiological mechanism is not clear, and the risk factors are numerous and common and are closely related to obesity, hypertension, diabetes, etc. The gut microbiota has many strains, which play a considerable part in normal digestion and absorption in the human body and the regulation of the immune response.

Role of A-Site Cation Hydrogen Bonds in Hybrid Organic-Inorganic Perovskites: A Theoretical Insight.

Hybrid organic-inorganic halide perovskites (HOIPs) have garnered a significant amount of attention due to their exceptional photoelectric conversion efficiency. However, they still face considerable challenges in large-scale applications, primarily due to their instability. One key factor influencing this instability is the lattice softness attributed to the A-site cations.

Baseline and cumulative Chinese visceral adiposity index and diabetic kidney disease: A prospective cohort study.

Background: Diabetic kidney disease (DKD) makes up nearly half of all chronic kidney disease cases and is a major cause of mortality for people with diabetes. However, the study of the association of longitudinal Chinese visceral adiposity index (CVAI) with DKD is still missing.

Methods: This prospective cohort study included 7874 diabetes patients from the Kailuan study.

Photo-Rechargeable Sodium-Ion Batteries with a Two-Dimensional MoSe Crystal Cathode.

Combining energy harvesting with energy storage systems in a single device could offer great advantages for continuous power supply in both indoor and outdoor electric applications. In this work, we demonstrate a photochargeable sodium-ion battery (PSIB) based on a photoactive cathode of two-dimensional crystals of MoSe. This photocathode enables spontaneous photodriven charging of a sodium-ion battery cathode under illumination and an increase in the reversible capacity to 29% at 600 mA g compared to that under dark conditions during galvanostatic cycling.

PSMA-Targeted Intracellular Self-Assembled Probe for Enhanced PET Imaging.

Positron-emission tomography (PET) offers high sensitivity for cancer diagnosis. However, small-molecule-based probes often exhibit insufficient accumulation in tumor sites, while nanoparticle-based agents typically have limited delivery efficiency. To address this challenge, this study proposes a novel PET imaging probe, Ga-CBT-PSMA, designed for prostate cancer.

Retrieving the Stability and Practical Performance of Activation-Unstable Mesoporous Zr(IV)-MOF for Highly Efficient Self-Calibrating Acidity Sensing.

The practical applications of activation-unstable mesoporous metal-organic frameworks (MOFs) are often constrained by their structural instability. However, enhancing their stability could unlock valuable functionalities. Herein, we stabilized the otherwise unstable, post-activated structure of a novel mesoporous Zr(IV)-MOF, NKM-809, which uses a pyridine-containing amphiprotic linker (PPTB).

Stretchable wrinkle-structured liquid metal sandwich films enable strain-insensitive electromagnetic shielding and Joule heating.

Stretchable electromagnetic interference (EMI) shields with strain-insensitive EMI shielding and Joule heating performances are highly desirable to be integrated with wearable electronics. To explore the possibility of applying geometric design in elastomeric liquid metal (LM) composites and fully investigate the influence of LM geometry on stretchable EMI shielding and Joule heating, multifunctional wrinkle-structured LM/Ecoflex sandwich films with excellent stretchability are developed. The denser LM wrinkle enables not only better electrical conduction, higher shielding effectiveness (SE) and steady-state temperature, but also enhanced strain-stable far-field/near-field shielding performance and Joule-heating capability.

Te@Se Core-Shell Heterostructures with Tunable Shell Thickness for Ultra-Stable NO Detection.

An effective long-term nitrogen dioxide (NO) monitoring at trace concentration is critical for protecting the ecological environment and public health. Tellurium (Te), as a recently discovered 2D elemental material, is promising for NO detection because of its suitable band structure for gas adsorption and charge mobility. However, the high activity of Te leads to poor stability in ambient and harsh conditions, limiting its application as a gas-sensitive material.

Smart and Noninvasive SERS Immunosensors for Monitoring Dynamic Expression of Cytokines during Cell Pyroptosis.

Accompanying the occurrence of inflammatory reaction to release cytokines, pyroptosis can activate an immune response for resistance against cancer. Consequently, elevated levels of cytokines released by cancer cells are highly correlated with the effectiveness of cancer treatment. Herein, a noninvasive surface-enhanced Raman spectroscopy (SERS) immunosensor was developed to sensitively and specifically measure the tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, during the cell pyroptosis process.