An innovative fluorescent probe based on dicyanoisoflurone derivatives for differential detection of Hg and Cu and its applications in bacteria, cell imaging and food analysis.

Background: Heavy metal pollution has become one of the world's most important environmental pollution, especially Hg is enriched, it is easy to enter the human body through the food chain, bind to the sulfhydryl group in the protein, cause mercury poisoning. Traditional methods for detecting Hg have obvious drawbacks, such as poor selectivity and long detection time. Fluorescence detection has attracted attention because of its good sensitivity and specificity detection ability.

An innovative near-infrared fluorescent probe with FRET effect for the continuous detection of Zn and PPi with high sensitivity and selectivity, and its application in bioimaging.

As the second most abundant transition metal element in the human body, zinc ions play an important role in the normal growth and development of the human body. We have successfully synthesized a near-infrared fluorescent probe with FRET effect for the detection of Zn. Probe DR6G has good selectivity and anti-interference ability for Zn.

A novel "on-off-on" near-infrared fluorescent probe for Cu and S continuous detection based on dicyanoisoflurone derivatives, and its application in bacterial imaging.

We have successfully synthesized a near-infrared fluorescent probe for the continuous detection of copper and sulfur ions. The probe has good selectivity and anti-interference ability against Cu and S. The results show that after adding Cu to the DL solution of the near-infrared fluorescent probe, Cu forms a [DL + Cu] complex with the probe, which leads to fluorescence quenching due to the paramagnetism of Cu.

Shear Stress and ROS Dual-Responsive RBC-Hitchhiking Nanoparticles for Atherosclerosis Therapy.

Atherosclerosis (AS), a leading cause of death worldwide, is a chronic inflammatory disease rich in lipids and reactive oxygen species (ROS) within plaques. Therefore, lowering lipid and ROS levels is effective in treating AS and reducing AS-induced mortality. In this study, an intelligent biomimetic drug delivery system that specifically responded to both shear stress and ROS microenvironment was developed, consisting of red blood cells (RBCs) and cross-linked polyethyleneimine nanoparticles (SA PEI) loaded with a lipid-lowering drug simvastatin acid (SA), and RBCs were self-assembled with SA PEI to obtain biresponsive SA PEI@RBCs for the treatment of AS.

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells. These three types of cells establish complex signals in the body and further influence tumor genesis, development, metastasis and participate in resistance to anti-tumor therapy. It has attracted scholars to study immune cells in TME due to the significant efficacy of immune checkpoint inhibitors (ICI) and chimeric antigen receptor T (CAR-T) in solid tumors and hematologic tumors.

Advances in electrospun nanofibrous membrane sensors for ion detection.

Harmful metal ions and toxic anions produced in industrial processes cause serious damage to the environment and human health. Chemical sensors are used as an efficient and convenient detection method for harmful ions. Electrospun fiber membranes are widely used in the field of solid-state chemical sensors due to high specific surface area, high porosity, and strong adsorption.

A novel hydrophilic fluorescent probe for Cu detection and imaging in HeLa cells.

Copper is an essential element in living systems and plays an important role in human physiology; therefore, methods to detect the concentration of copper ions in living organisms are important. Herein, we report a highly water-soluble naphthalimide-based fluorescent probe that can be used for the detection of Cu. The probe, BNQ, has high selectivity and sensitivity.

A novel fluorescent probe with aggregation induced emission (AIE) effect based on 1,4-dihydropyridine and its applications.

A fluorescent hydrazine hydrate probe (DMA) based on 1,4-dihydropyridine derivatives was designed and synthesized. The fluorescence emission peak of this probe is in the near-infrared region (667 nm), which has good selectivity to hydrazine hydrate and low detection limit (11 nM). Importantly, the probe exhibits aggregation-induced emission (AIE) characteristics.

A novel fluorescent probe based on a triphenylamine derivative for the detection of HSO with high sensitivity and selectivity.

A novel highly active fluorescence chemical sensor (TBQN) for HSO was synthesized by the Knoevenagel reaction based on triphenylamine-benzothiazole as a new fluorophore. The probe possessed good selectivity toward HSO and anti-interference ability with common ions. The fluorescence and UV-vis spectra of the TBQN probe were significantly changed after the addition of HSO.

A novel 100% aqueous solution near-infrared ratiometric fluorescent CN- probe based on 1,4-dihydropyridines, with a large fluorescent emission peak shift.

1,4-Dihydropyridines are a class of drugs with a wide range of biological activities and pharmacological effects. However, there are few reports on its optical activity, especially its application on fluorescent CN probe. In this experiment, we designed and synthesized a fluorescent probe based on 1,4-dihydropyridines to detect CN.

A novel ratiometric fluorescent probe for differential detection of HSO and ClO and application in cell imaging and tumor recognition.

By connecting 1,8-naphthalimide and indole sulfonate, a ratio fluorescent probe capable of differential detection of hydrogen sulfite and hypochlorite was synthesized for the first time. It was able to achieve the qualitative detection of HSO and ClO with high sensitivity and selectivity, respectively. It provides a multi-purpose probe and is based on different emission channels without mutual interference.