Publications by authors named "Liangping Ruan"
miR-542-5p targets GREM1 to affect the progression of renal fibrosis.
J Biochem Mol Toxicol
September 2024
Article Synopsis
- Renal fibrosis (RF) is a major feature of serious kidney diseases like chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD), but its regulatory mechanisms are not fully understood.
- Researchers analyzed microRNA (miRNA) expression through the GEO database and identified key miRNAs involved in RF; notably, miR-574-5p and miR-542-5p were highlighted for their roles in renal fibrosis.
- Experimental studies in mouse models and kidney cells showed that miR-542-5p is downregulated, while its target gene, GREM1, is upregulated, indicating a regulatory relationship that could impact the development of renal fibrosis.