Macroscopic and microscopic analysis of the effects of moisture content and dry density on the strength of loess.

To clarify the impact of moisture content and dry density on the strength of loess, the remolded loess samples with different moisture content and dry density were prepared, and the influence of moisture content and dry density on loess strength was explored from the macro level by direct shear test without suction control. On this basis, the mechanism of the influence of moisture content and dry density on loess strength was explored from the micro level by nuclear magnetic resonance method. The research results indicate that: In the case of low water content, there are peak points in the stress-strain curve of remolded loess, exhibiting strain softening characteristics.

Corrigendum: Active substances of myxobacteria against plant diseases and their action mechanisms.

[This corrects the article DOI: 10.3389/fmicb.2023.

Causal association study of the dynamic development of the metabolic syndrome based on longitudinal data.

The dynamic progression of metabolic syndrome (MetS) includes developmental deterioration and reverse recovery; however, the key factors in this bidirectional progression have not been identified. Our study aimed to use the data obtained from the China Health and Retirement Longitudinal Study (CHARLS) and construct a Bayesian network to explore the causal relationship between influential factor and the development and recovery of MetS. Followed up at 4 years, forward progression of MetS occurred in 1543 and reverse recovery of MetS occurred in 1319 of 5581 subjects.

Tunnel construction in shallow soft rock using the pipe shed support.

In order to clarify the impact mechanism of shallow buried soft rock tunnel excavation on the upper existing highway, as well as the mechanism of pipe shed reinforcement, a combination of theoretical analysis and on-site monitoring was used to conduct in-depth research on the Diantou Tunnel Crossing the existing highway project of Dayong Expressway. The impact of shallow buried soft rock tunnel crossing construction on the existing highway and safety control issues were studied, a new deformation control index, namely deformation difference rate, was introduced. The results show that the main lateral area of influence of rock deformation is within a distance of one diameter, and the overall area of influence is within a distance of twice the diameter.

Active substances of myxobacteria against plant diseases and their action mechanisms.

Myxobacteria have a complex life cycle and unique social behavior, and obtain nutrients by preying on bacteria and fungi in soil. Chitinase, β-1,3 glucanase and β-1,6 glucanase produced by myxobacteria can degrade the glycosidic bond of cell wall of some plant pathogenic fungi, resulting in a perforated structure in the cell wall. In addition, isooctanol produced by myxobacteria can lead to the accumulation of intracellular reactive oxygen species in some pathogenic fungi and induce cell apoptosis.

Study on Quench Sensitivity during Isothermal Treatment of 7A65 Aluminum Alloy.

The quenching sensitivity of 7A65 aluminum alloy was investigated using interrupted quenching experiments. The time-temperature transformation (TTT) and time-temperature performance (TTP) curves of the alloy were determined. The results indicate that the nose temperature is about 320 °C and the quenching sensitivity temperature range is from 240 °C to 360 °C.

Chitooligosaccharide-induced plant stress resistance.

In nature, the production of plant stress resistance traits is often induced by extreme environmental conditions. Under extreme conditions, plants can be irreversibly damaged. Intervention with phytostimulants, however, can improve plant stress resistance without causing damage to the plants themselves, hence maintaining the production.

The preparation and antioxidant activities of three phenyl-acylchitooligosaccharides.

Chitooligosaccharides with two different molecular weights are acylated with three containing benzene carboxylic acids: salicylic acid (BHA), α-naphthylacetic acid (NAA) and indole-3-butyric acid (IBA) to obtain o-hydroxybenzoyl-chitooligosaccharide, α-naphthylacetyl-chitooligosaccharide, and 3-Indolebutyryl-chitooligosaccharide. The structure of the derivatives was characterized by FT-IR spectroscopy, C NMR spectroscopy and elemental analysis. According to several amide characteristic absorption peaks between 1750 cm-1500 cm in the FT-IR spectrum, it can be determined that the target group has been successfully grafted.

The preparation and antioxidant activities of four 2-aminoacyl-chitooligosaccharides.

Chitooligosaccharides (COS) with two different molecular weights are acylated with four nonpolar amino acids: glycine (Gly), alanine (Ala), valine (Val) and leucine (Leu) to obtain 2-aminoacetyl-chitooligosaccharide (2-GlyCOS), 2-aminopropionyl-chitooligosaccharide (2-AlaCOS), 2-amino-3-methylbutyryl-chitooligosaccharide (2-ValCOS), and 2-amino-4-methylpentanoyl-chitooligosaccharide (2-LeuCOS). The structure of the derivatives was characterized by FT-IR spectroscopy, C NMR spectroscopy, and elemental analysis. The antioxidant activities of the derivatives, such as hydroxyl radical (·OH) scavenging ability, superoxide anion (O·) scavenging ability, reducing ability, and DPPH radical scavenging ability, were investigated using various established systems.

Opening the black box: interpretable machine learning for predictor finding of metabolic syndrome.

Objective: The internal workings ofmachine learning algorithms are complex and considered as low-interpretation "black box" models, making it difficult for domain experts to understand and trust these complex models. The study uses metabolic syndrome (MetS) as the entry point to analyze and evaluate the application value of model interpretability methods in dealing with difficult interpretation of predictive models.

Methods: The study collects data from a chain of health examination institution in Urumqi from 2017 ~ 2019, and performs 39,134 remaining data after preprocessing such as deletion and filling.

Relationship between vitamin D receptor gene polymorphisms and second acid-fast bacilli smear-positive during treatment for tuberculosis patients.

Purpose: Tuberculosis (TB) treatment is associated with Vitamin D. This study aimed to explore the relationship between Vitamin D receptor (VDR) gene polymorphisms and second acid-fast bacilli (AFB) smear-positive during treatment for TB patients.

Methods: This was a cross-sectional study.

The relationship between vitamin D level and second acid-fast bacilli (AFB) smear-positive during treatment for TB patients was inferred by Bayesian network.

Background: Vitamin D is related to human immunity, so we used Bayesian network model to analyze and infer the relationship between vitamin D level and the acid-fast bacilli (AFB) smear-positive after two months treatment among pulmonary tuberculosis (TB) patients.

Methods: This is a cross-sectional study. 731 TB patients whose vitamin D level were detected and medical records were collected from December 2019 to December 2020 in XinJiang of China.

Construction of Xinjiang metabolic syndrome risk prediction model based on interpretable models.

Background: We aimed to construct simple and practical metabolic syndrome (MetS) risk prediction models based on the data of inhabitants of Urumqi and to provide a methodological reference for the prevention and control of MetS.

Methods: This is a cross-sectional study conducted in the Xinjiang Uygur Autonomous Region of China. We collected data from inhabitants of Urumqi from 2018 to 2019, including demographic characteristics, anthropometric indicators, living habits and family history.

Experimental study of land subsidence in response to groundwater withdrawal and recharge in Changping District of Beijing.

Over exploitation of groundwater in Changping District of Beijing city has caused serious land subsidence in the past decades. In recent years, the operation of the South-to-North Water Transfer Project has reduced the land subsidence rate. In this paper, Experimental tests are performed using the GDS Consolidation Testing System to characterize the compression and rebound of soils at depths of less than 100 m caused by groundwater withdrawal and recharge in Changping District.

Cp*Rh-Catalyzed Sulfonamide-Directed Ortho Arene C-H Carbenoid Functionalization with Pyridotriazoles.

In this Letter, triazoles as carbene reagents were used for sulfonamide-directed C-H insertion carbenoid functionalization to construct benzylpyridine sulfonamide dual-pharmacophore compounds. This method is simple and efficient and can be used for the late-stage modification of sulfonamide drugs.

Hybrid of Resveratrol and Glucosamine: An Approach To Enhance Antioxidant Effect against DNA Oxidation.

Resveratrol exhibits various pharmacological activities, which are dependent upon phenolic hydroxyl groups. In this work, glucosamine, lipoic acid, or adamantanamine moiety was applied for attaching to ortho-position of hydroxyl group in resorcinol moiety of resveratrol (known as position-2). Antioxidant effects of the obtained hybrids were characterized using DNA oxidative systems mediated by OH, Cu/glutathione (GSH), and 2,2'-azobis(2-amidinopropanehydrochloride) (AAPH), respectively.

Tetrahydropyrrolization of Resveratrol and Other Stilbenes Improves Inhibitory Effects on DNA Oxidation.

The inhibitory effect of resveratrol on DNA oxidation caused by 2,2'-azobis(2-amidinopropane hydrochloride) (AAPH) was found to be enhanced if the C=C bond in resveratrol was converted into tetrahydropyrrole by reaction with azomethine ylide (CH2 =N(+) (CH3 )CH2 (-) ). This encouraged us to explore whether the inhibitory activities of other stilbenes could also be increased by the same method. We found that the inhibitory effects of the tetrahydropyrrole derivatives on AAPH-induced oxidation of DNA were higher than those of the corresponding stilbenes, because the tetrahydropyrrole motif can provide hydrogen atoms to be abstracted by radicals.

Synthesis and biological evaluation of 1,2,4-trisubstituted imidazoles as inhibitors of transforming growth factor-β type I receptor (ALK5).

A series of 2-(6-methylpyridin-2-yl)-1H-imidazoles were synthesized and evaluated for ALK5 inhibitory activity in cell-based luciferase reporter assays. The compound 4-(((1-(benzo[d][1,3]dioxol-5-yl)-2-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)methyl)amino)benzenesulfonamide (27a) exhibited slightly higher inhibition (IC50=0.24μM) than SB431542 (IC50=0.